Author

T. Gebremariam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 5 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Y. Gu· 6 shared A. S. Ibrahim· 5 shared S. Alkhazraji· 4 shared A. Alqarihi· 3 shared E. Youssef· 3 shared S. Filler· 3 shared A. Ibrahim· 2 shared J. Edwards· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersMicrobiology

Y. Gu

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Efficacy of an oral lipid nanocrystal (LNC) formulation of amphotericin B (MAT2203) in the neutropenic mouse model of pulmonary mucormycosis

Y. Gu, T. Gebremariam, S. Alkhazraji, E. Youssef, S. El-Gamal, T. Matkovits, J. Cobb, R. Mannino, A. Ibrahim

This study compares the efficacy of oral MAT2203 to intravenous LAMB in a neutropenic mouse model of mucormycosis, finding MAT2203 as effective in survival and fungal burden reduction.

bioRxiv · Nov 22, 2023Microbiology

CotH genes are necessary for normal spore formation and virulence in Mucor lusitanicus

C. Szebenyi, Y. Gu, T. Gebremariam, S. Kocsube, S. Kiss-Vetrab, O. Jager, R. Patai, K. Spisak, R. Sinka, U. Binder, M. Homa, C. Vagvölgyi, A. S. Ibrahim, G. Nagy, T. Papp

This study identifies CotH genes in Mucor lusitanicus and shows their role in spore formation, virulence, and cell wall structure through CRISPR-Cas9 disruption and infection models.

bioRxiv · Dec 9, 2022 · PreprintMicrobiology

Niclosamide loaded Eudragit EPO nanoparticles show enhanced Candida biofilm penetration, trigger biofilm detachment and protect from mucosal candidiasis

Y. Sutar, S. Nabeela, S. Singh, A. Alqarihi, N. V. Solis, T. Gebremariam, S. Filler, A. Ibrahim, A. Date, P. Uppuluri

This study identifies Niclosamide as a drug that disrupts Candida biofilms and develops nanoparticles to enhance its efficacy against drug-resistant strains.

bioRxiv · Jun 2, 2022 · PreprintMicrobiology

Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis

S. Soliman, C. Baldin, Y. Gu, S. Singh, T. Gebremariam, M. Swidergall, A. Alqarihi, E. Youssef, S. Alkhazraji, A. Pikoulas, C. Perske, V. Venkataramani, A. Rich, V. M. Bruno, J. C. Dunning Hotopp, , A. S. Ibrahim

This paper identifies mucoricin, a ricin-like toxin produced by Mucorales fungi, critical for mucormycosis pathogenesis and a potential therapeutic target.

bioRxiv · Jan 13, 2021Microbiology

Environmental interactions with amoebae as drivers of bacterial-fungal endosymbiosis and pathogenicity

H. Itabangi, P. Sephton-Clark, X. Zhou, G. P. Starling, Z. Mahamoud, I. Insua, M. Probert, J. Correia, P. Moynihan, Y. Gu, T. Gebremariam, A. S. Ibrahim, G. D. Brown, J. S. King, E. R. Ballou, K. Voelz

The paper identifies a bacterial endosymbiont in Rhizopus microsporus that enhances fungal virulence by suppressing amoeba predation and macrophage clearance.

bioRxiv · Dec 17, 2020 · PreprintMicrobiology

GRP78 and Integrins Play Different Roles in Host Cell Invasion During Mucormycosis

A. Alqarihi, T. Gebremariam, Y. Gu, M. Swidergall, S. Alkhazraji, s. Soliman, V. Bruno, J. Edwards, S. Filler, P. Uppuluri, A. S. Ibrahim

This study identifies GRP78 and integrins as distinct host receptors for Rhizopus delemar invasion in nasal and alveolar epithelial cells, explaining differential mucormycosis susceptibility in DKA and hematologic malignancy patients.

bioRxiv · Apr 29, 2020Microbiology

Preserving Vascular Integrity Protects Mice Against Multidrug-Resistant Gram-Negative Bacterial Infection

T. Gebremariam, L. Zhang, S. Alkhazraji, Y. Gu, E. Youssef, Z. Tong, E. Kish-Trier, C. V. Araujo, B. Rich, S. W. French, D. Li, A. Mueller, S. Odelberg, W. Zhu, A. S. Ibrahim

This study shows that inhibiting ARF6 protects mice from MDR Gram-negative bacterial infections by preserving vascular integrity.

bioRxiv · Feb 18, 2020Microbiology