Author

S. Filler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Assay:proteomics· 5 Organism:C. elegans· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Alqarihi· 4 shared P. Uppuluri· 4 shared A. S. Ibrahim· 3 shared M. Swidergall· 3 shared N. Solis· 3 shared S. Singh· 3 shared T. Gebremariam· 3 shared J. Edwards· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersMicrobiology

A. Alqarihi

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Candida albicans oropharyngeal infection is an exception to iron-based nutritional immunity

N. V. Solis, R. S. Wakade, S. Filler, D. J. Krysan

This study compares C. albicans gene expression in oral and kidney infections, finding it is iron-replete in oral tissue but iron-starved in the kidney, suggesting exemption from iron-based nutritional immunity in oral infections.

bioRxiv · Jan 11, 2023 · PreprintMicrobiology

Niclosamide loaded Eudragit EPO nanoparticles show enhanced Candida biofilm penetration, trigger biofilm detachment and protect from mucosal candidiasis

Y. Sutar, S. Nabeela, S. Singh, A. Alqarihi, N. V. Solis, T. Gebremariam, S. Filler, A. Ibrahim, A. Date, P. Uppuluri

This study identifies Niclosamide as a drug that disrupts Candida biofilms and develops nanoparticles to enhance its efficacy against drug-resistant strains.

bioRxiv · Jun 2, 2022 · PreprintMicrobiology

Plasma membrane phosphatidylinositol-4-phosphate is not necessary for Candida albicans viability, yet is key for cell wall integrity and systemic infection

R. Garcia-Rodas, H. Labbaoui, F. Orange, N. Solis, O. Zaragoza, S. Filler, M. Bassilana, R. A. Arkowitz

This study shows plasma membrane PI(4)P is not essential for Candida albicans viability but is critical for filamentation, cell wall integrity, and virulence in systemic infections.

bioRxiv · Dec 31, 2021Cell Biology

Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis

S. Soliman, C. Baldin, Y. Gu, S. Singh, T. Gebremariam, M. Swidergall, A. Alqarihi, E. Youssef, S. Alkhazraji, A. Pikoulas, C. Perske, V. Venkataramani, A. Rich, V. M. Bruno, J. C. Dunning Hotopp, , A. S. Ibrahim

This paper identifies mucoricin, a ricin-like toxin produced by Mucorales fungi, critical for mucormycosis pathogenesis and a potential therapeutic target.

bioRxiv · Jan 13, 2021Microbiology

Control of ss-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence

M. Yang, N. Solis, M. Marshall, R. A. Garleb, T. Zhou, D. Wang, M. Swidergall, E. Pearlman, S. Filler, H. Liu

This study shows that Eng1 and Ywp1 in C. albicans reduce Dectin-1 binding by masking β-glucans, thereby decreasing immune recognition and virulence.

bioRxiv · Sep 7, 2020Microbiology

GRP78 and Integrins Play Different Roles in Host Cell Invasion During Mucormycosis

A. Alqarihi, T. Gebremariam, Y. Gu, M. Swidergall, S. Alkhazraji, s. Soliman, V. Bruno, J. Edwards, S. Filler, P. Uppuluri, A. S. Ibrahim

This study identifies GRP78 and integrins as distinct host receptors for Rhizopus delemar invasion in nasal and alveolar epithelial cells, explaining differential mucormycosis susceptibility in DKA and hematologic malignancy patients.

bioRxiv · Apr 29, 2020Microbiology

Human Als3p Antibodies are Surrogate Markers of NDV-3A Vaccine Efficacy Against Recurrent Vulvovaginal Candidiasis

P. Uppuluri, S. Singh, A. Alqarihi, C. S. Schmidt, J. P. Hennessey, M. R. Yeaman, S. Filler, J. E. Edwards, A. S. Ibrahim

The paper evaluates anti-Als3p antibodies as surrogate markers for NDV-3A vaccine efficacy against recurrent vulvovaginal candidiasis by comparing vaccinated individuals with and without recurrence.

bioRxiv · May 17, 2018Immunology

Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence

N.-N. Liu, P. Uppuluri, A. Broggi, A. Besold, K. Ryman, H. Kambara, N. Solis, V. Lorenz, W. Qi, M. Acosta Zaldivar, S. N. Emami, B. Bao, D. An, F. Bonilla, M. Sola-Visner, , J. R. Koehler

This study shows that Pho84 in Candida albicans affects virulence by modulating oxidative stress through Sod3 and TORC1 pathways.

bioRxiv · May 11, 2018Microbiology