Author

Piet C. Aerts

University Medical Center Utrecht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 1

Frequent Co-Authors

Carla J. C. de HaasiD· 2 shared Suzan H. M. RooijakkersiD· 2 shared Albert BondtiD· 1 shared Albert J. R. HeckiD· 1 shared Arjan Barendregt· 1 shared Bart W. BardoeliD· 1 shared Dorien Kos· 1 shared Gerard J. van Mierlo· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Carla J. C. de HaasORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

C1q-mediated steric hindrance limits FcγR contribution to antibody-driven phagocytosis by human neutrophils

Max L.B. Grönloh, Lisanne de Vor, Seline A. Zwarthoff, Jana Venema, Rosemieke Smits, Stan Baijens, Maartje Ruyken, Piet C. Aerts, Carla J. C. de Haas, Kok P. M. van Kessel, Leendert Adrianus Trouw, Bart W. Bardoel, Suzan H. M. Rooijakkers

This study shows that complement proteins like C1q block FcγR engagement with IgG, reducing their role in neutrophil phagocytosis, while complement receptors still enhance bacterial clearance.

bioRxiv · Oct 7, 2026 · PreprintImmunology

CD5L is a canonical component of circulatory IgM

Nienke Oskam, Maurits A. den Boer, Marie Vestergaard Lukassen, Pleuni Ooijevaar‐de Heer, Tim S. Veth, Gerard J. van Mierlo, Szu‐Hsueh Lai, Ninotska I. L. Derksen, Victor C. Yin, Marij Streutker, Vojtěch Franc, Marta Šiborová, Mirjam J. A. Damen, Dorien Kos, Arjan Barendregt, , Albert J. R. Heck

The paper identifies CD5L as a component of circulatory IgM, showing it forms a complex with J-chain-containing pentamers and affects IgM receptor binding.

Proceedings of the National Academy of Sciences · Dec 6, 2023Peer-reviewedMolecular Biology