Author

R. E. Gerszten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 3 Assay:metabolomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

X. Shi· 4 shared C. B. Clish· 2 shared J. Z. Long· 2 shared S. Deng· 2 shared U. Tahir· 2 shared V. L. Li· 2 shared W. Wei· 2 shared X. Lyu· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCell Biology

X. Shi

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Author profile →

5 papers

Recent·Most cited

Mitochondrial choline import regulates purine nucleotide pools via SLC25A48

A. R. P. Verkerke, X. Shi, I. Abe, R. E. Gerszten, S. Kajimura

This study identifies SLC25A48 as a mitochondrial carrier that mediates choline import, regulating purine nucleotide synthesis and cell survival.

Cell Metabolism · Sep 1, 2024Peer-reviewedCell Biology

Lac-Phe mediates the anti-obesity effect of metformin

S. Xiao, V. L. Li, X. Lyu, X. Chen, W. Wei, F. Abbasi, J. Knowles, S. Deng, G. Tiwari, X. Shi, S. Deng, L. Farrell, Z.-Z. Chen, K. Taylor, X. Guo, , J. Z. Long

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

bioRxiv · Nov 2, 2023 · PreprintPhysiology

CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels

J. T. Tanzo, V. L. Li, A. L. Wiggenhorn, M. D. M. Garzon, W. Wei, X. Lyu, W. Dong, U. Tahir, Z.-Z. Chen, D. E. Cruz, S. Deng, X. Shi, S. Zheng, Y. Guo, M. Sims, , M. D. Benson

The paper identifies CYP4F2 as a human-specific genetic determinant of plasma N-acyl amino acid levels and shows its role in metabolic diversification.

bioRxiv · Mar 9, 2023Biochemistry

Modeling of Alpha-1 Antitrypsin Deficiency with Syngeneic Human iPSC-Hepatocytes Reveals Metabolic Dysregulation and Cellular Heterogeneity in PiMZ and PiZZ Hepatocytes

J. Kaserman, R. B. Werder, F. Wang, T. Matte, M. I. Higgins, M. Dodge, J. Lindstrom-Vautrin, A. Hinds, E. Bullitt, I. Caballero, X. Shi, R. E. Gerszten, N. Brunetti-Pierri, M. Liesa, C. Villacorta-Martin, , A. A. Wilson

This study uses CRISPR-Cas9 to create syngeneic iPSC-derived hepatocytes with ZAAT heterozygosity, revealing metabolic dysregulation and cellular heterogeneity in MZ and ZZ cells.

bioRxiv · Feb 1, 2022 · PreprintCell Biology

Metabolomic profiling identifies complex lipid species associated with response to weight loss interventions

N. A. Bihlmeyer, L. C. Kwee, C. B. Clish, A. A. Deik, R. E. Gerszten, N. J. Pagidipati, B. Laferrere, L. P. Svetkey, C. B. Newgard, W. E. Kraus, S. H. Shah

The paper identifies metabolites, particularly lipids, associated with response to weight loss interventions and highlights their role in metabolic heterogeneity.

bioRxiv · Oct 5, 2020Physiology