Author

R. E. Moellering

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:proteomics· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

B. D. Stein· 2 shared D. Wu· 2 shared L. C. Cantley· 2 shared A. Gonzalez· 1 shared A. J. Carlos· 1 shared A. Mohamed· 1 shared A. Valdespino· 1 shared B. Ngo· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

B. D. Stein

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

L. C. Nguyen, D. M. Renner, D. Silva, D. Yang, N. Parenti, K. M. Medina, V. Nicolaescu, H. Gula, N. Drayman, A. Valdespino, A. Mohamed, C. Dann, K. Wannemo, L. Robinson-Mailman, A. Gonzalez, , S. R. Weiss

This study compares how SARS-CoV-2 and other betacoronaviruses activate the IRE1α/XBP1 ER stress pathway in human lung cells, finding that SARS-CoV-2 only partially activates it, potentially evading host immune detection.

bioRxiv · Dec 30, 2021 · PreprintMicrobiology

Non-conserved metabolic regulation by LKB1 distinguishes human and mouse lung adenocarcinoma

B. D. Stein, J. R. Ferrarone, E. E. Gardner, J. W. Chang, D. Wu, Q. Chen, P. E. Hollstein, M. Yuan, R. J. Liang, J. S. Coukos, M. Sindelar, B. Ngo, S. S. Gross, R. J. Shaw, J. M. Asara, , L. C. Cantley

This study identifies a metabolic divergence between human and mouse lung adenocarcinomas due to LKB1-dependent regulation of TPI1 phosphorylation, highlighting limitations of mouse models for studying human cancer.

bioRxiv · Oct 1, 2021 · PreprintCancer Biology

Diverse Hotspot Thermal Profiling Methods Detect Phosphorylation-Dependent Changes in Protein Stability

B. D. Stein, J. X. Huang, D. Wu, L. C. Cantley, R. E. Moellering

The paper compares two HTP methods, finding that LFE-HTP improves proteoform coverage and detects novel phosphorylation sites affecting protein stability.

bioRxiv · May 1, 2021 · PreprintBiochemistry

Photoproximity profiling of protein-protein interactions in cells

D. C. McCutcheon, G. Lee, A. J. Carlos, J. E. Montgomery, R. E. Moellering

This paper introduces a method to map protein-protein interactions in live cells using a light-activated probe and validates its application on KEAP1 interactions under different cellular conditions.

Journal of the American Chemical Society · Dec 10, 2019Peer-reviewedBiochemistry