L. Yue

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysis

metaExpertPro constructs metaproteomics spectral libraries and analyzes DIA-MS data, achieving high peptide quantification and low FDR in human fecal samples.

PPARγ controls ESCRT-dependent fibroblast-like synoviocyte exosome biogenesis and Alleviates Chondrocyte Osteoarthritis Mediated by Exosomal ANXA1

This study shows that PPARγ enhances exosome biogenesis in fibroblast-like synoviocytes via the ESCRT pathway, and these exosomes containing ANXA1 alleviate osteoarthritis by inhibiting ERK phosphorylation and chondrocyte apoptosis.

Single-cell transcriptome analysis reveals the cellular atlas of human intracranial aneurysm and highlights inflammation features associated with aneurysm rupture

This study uses single-cell transcriptomics to analyze human intracranial aneurysm tissue, identifying immune cell features linked to aneurysm rupture.

Structural insights into regulation of TRPM7 divalent cation uptake by the small GTPase ARL15

This study identifies ARL15 as a GTPase that binds CNNM2 and inhibits TRPM7-mediated divalent cation uptake, revealing molecular interactions and competitive regulation with PRL2.

Integrative genetic analysis identifies FLVCR1 as an essential component of choline transport in mammals

The paper identifies FLVCR1 as essential for choline transport in mammals through integrative genetic analysis and functional studies.

Phospholipase Cβ2 Promotes Vascular Endothelial Growth Factor Induced Vascular Permeability

This study identifies PLCβ2 as a key regulator of VEGF-induced vascular permeability by modulating calcium flux and PIP2 levels, showing therapeutic potential for diseases involving vascular leakage.

Replication Study: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

This replication study confirms some findings of the original study on RAF inhibitors and their effects on MAPK pathway activation but reports discrepancies in key experiments.

Oxalic acid binds to gustatory receptor Gr23a and inhibits feeding in the brown planthopper

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

TRPM2 deficiency protects against atherosclerosis by inhibiting TRPM2-CD36 inflammatory axis in macrophages

This study shows TRPM2 deficiency protects against atherosclerosis by inhibiting the TRPM2-CD36 inflammatory axis in macrophages, reducing plaque burden and inflammation.

aCPSF1 in synergy with terminator U-tract dictates archaeal transcription termination efficiency via the KH domains recognizing U-tract

This paper identifies aCPSF1 and terminator U-tract synergy in archaeal transcription termination, showing their roles in determining termination efficiency through KH domain binding and nuclease activity.

Three bacterium-plasmid golden combinations facilitate the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China

The paper identifies three plasmid combinations that enhance the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China through genomic and epidemiological analysis.

Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response

The paper uses computational models to identify immunogenic regions in the HIV proteome by analyzing HLA diversity and CD8 T-cell immune repertoires, offering a pipeline for vaccine design.

aCPSF1 controlled archaeal transcription termination: a prototypical eukaryotic model

This paper identifies aCPSF1 as the first general transcription termination factor in Archaea, revealing its cleavage-dependent termination mechanism and evolutionary relationship to eukaryotic processes.