Author

K. E. Lawrence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

C. Sawyers· 2 shared A. C. Perez· 1 shared A. Gopalan· 1 shared A. Vanden Broeck· 1 shared B. Wang· 1 shared C. Firat· 1 shared C. L. Sawyers· 1 shared C. Mao· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

C. Sawyers

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

R. Romero, T. Chu, T. J. Gonzalez-Robles, P. Smith, Y. Xie, H. Kaur, S. Yoder, H. Zhao, C. Mao, W. Kang, M. Pulina, K. E. Lawrence, A. Gopalan, S. Zaidi, K. Yoo, , C. Sawyers

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

bioRxiv · Apr 9, 2024Cancer Biology

Allosteric interactions prime androgen receptor dimerization and activation

E. Wasmuth, A. Vanden Broeck, J. R. LaClair, E. A. Hoover, K. E. Lawrence, N. Paknejad, K. J. Pappas, D. Matthies, B. Wang, W. Feng, P. A. Watson, J. C. Zinder, W. Karthaus, M. J. de la Cruz, R. K. Hite, , C. Sawyers

This study identifies allosteric interactions that prime androgen receptor dimerization and activation, revealing structural and functional mechanisms relevant to development and disease.

bioRxiv · Feb 20, 2022Biochemistry

A new immunocompetent rectal cancer model to study radiation therapy

J. K. Kim, C. Wu, M. Del Latto, Y. Gao, S.-H. Choi, M. Kierstead, C.-E. G. Sauve, C. Firat, A. C. Perez, J. Sillanpaa, C.-T. Chen, K. E. Lawrence, P. B. Paty, F. M. Barriga, J. Shia, , J. J. Smith

This paper introduces a mouse model of rectal cancer that mimics human tumor progression and radiation response for preclinical studies.

bioRxiv · Feb 7, 2022 · PreprintCancer Biology