Author

F. T. Zakusilo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:mouse· 1

Frequent Co-Authors

A. Seluanov· 2 shared J. Ablaeva· 2 shared J. Y. Lu· 2 shared V. Gorbunova· 2 shared Z. Zhang· 2 shared A. Tyshkovskiy· 1 shared D. Firsanov· 1 shared E. Hillpot· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersEvolutionary Biology

A. Seluanov

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2 papers

Recent·Most cited

Evolution of High-Molecular-Mass Hyaluronic Acid is Associated with Subterranean Lifestyle

Y. Zhao, Z. Zheng, Z. Zhang, E. Hillpot, Y. S. Lin, F. T. Zakusilo, J. Y. Lu, J. Ablaeva, R. A. Miller, E. Nevo, A. Seluanov, V. Gorbunova

The paper identifies that subterranean mammals have abundant high-molecular-mass HA due to genetic changes, which may aid in cancer resistance and adaptation to hypoxic environments.

bioRxiv · May 8, 2023Evolutionary Biology

Increased hyaluronan by naked mole-rat HAS2 extends lifespan in mice

Z. Zhang, X. Tian, J. Y. Lu, K. Boit, J. Ablaeva, F. T. Zakusilo, S. Emmrich, D. Firsanov, E. Rydkina, S. A. Biashad, Q. Lu, A. Tyshkovskiy, V. N. Gladyshev, S. Horvath, A. Seluanov, V. Gorbunova

This study shows that overexpressing the naked mole-rat HAS2 gene in mice increases hyaluronan levels, reduces inflammation, and extends lifespan and healthspan.

bioRxiv · May 4, 2023 · PreprintPhysiology