S. F. Andrews

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination

This study examines how prior H2 influenza exposure influences polyclonal antibody responses to H2N2 vaccination, showing differences in epitope targeting between H2-exposed and H2-naive individuals.

C1q Enables Influenza HA Stem Binding Antibodies to Block Viral Attachment and Broadens the Antibody Escape Repertoire

This study shows that C1q enhances anti-hemagglutinin stem antibody neutralization by blocking viral attachment and expanding the viral escape repertoire.

Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings

This study applies Bcl-6/Bcl-xL retroviral transduction to isolate antibodies and generate B cell clones from various B cell populations in healthy and infected individuals.

Using Neutralization Landscapes to enumerate Antibody Behavior and Decompose Antibody Mixtures

The paper introduces a Neutralization Landscape to analyze antibody-virus interactions and decompose antibody mixtures targeting influenza hemagglutinin stem proteins.

A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

The paper develops a fluorescent reporter virus panel to enable high-throughput neutralization profiling of influenza antibodies without requiring high-containment labs.

Design of nanoparticulate group 2 influenza hemagglutinin stem antigens that activate unmutated ancestor B cell receptors of broadly neutralizing antibody lineages

This study designs nanoparticle-based influenza HA stem antigens that activate unmutated B cell receptors of broadly neutralizing antibodies, potentially enabling cross-group immunity.