Author

H. R. Perrett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. B. Ward· 4 shared R. W. Sanders· 4 shared A. Antanasijevic· 3 shared J. A. Burger· 3 shared M. Crispin· 3 shared P. J. M. Brouwer· 3 shared T. Strecker· 2 shared Y. R. Yang· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersImmunology

A. B. Ward

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Author profile →

5 papers

Recent·Most cited

Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses

P. J. M. Brouwer, H. R. Perrett, T. Beaumont, H. Nijhuis, S. Kruijer, J. A. Burger, W.-H. Lee, H. Muller-Krauter, R. W. Sanders, T. Strecker, M. J. van Gils, A. B. Ward

This study identifies neutralizing antibody epitopes against Lassa virus GPC using electron microscopy, revealing challenges in vaccine-induced responses and opportunities for improved vaccine design.

bioRxiv · Dec 21, 2023Immunology

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination

Y. R. Yang, J. Han, H. R. Perrett, S. T. Richey, A. M. Jackson, A. J. Rodriguez, R. A. Gillespie, S. O'Connell, J. E. Raab, L. Y. Cominsky, A. Chopde, M. Kanekiyo, K. V. Houser, G. L. Chen, A. B. McDermott, , A. B. Ward

This study examines how prior H2 influenza exposure influences polyclonal antibody responses to H2N2 vaccination, showing differences in epitope targeting between H2-exposed and H2-naive individuals.

bioRxiv · Aug 23, 2023Immunology

Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies

H. R. Perrett, P. J. M. Brouwer, J. Hurtado, M. L. Newby, J. A. Burger, L. Liu, J. H. Bouhuijs, G. Gibson, T. Messmer, J. S. Schieffelin, A. Antanasijevic, G.-J. Boons, M. Crispin, R. W. Sanders, B. Briney, A. B. Ward

The paper structures and characterizes Lassa virus glycoproteins from multiple lineages and identifies neutralizing antibodies that target conserved epitopes.

bioRxiv · Sep 26, 2022Immunology

Lassa virus glycoprotein nanoparticles elicit a neutralizing antibody that defines a new site of vulnerability

P. J. M. Brouwer, A. Antanasijevic, A. J. Ronk, H. Mulller-Krauter, Y. Watanabe, M. Claireaux, N. M. Lloyd, T. P. L. Bijl, H. R. Perrett, T. H. Steijaert, J. A. Burger, M. M. van Haaren, K. Sliepen, M. van Gils, M. Crispin, , R. W. Sanders

This study develops Lassa virus glycoprotein nanoparticles that stabilize GPC trimers and elicit neutralizing antibodies targeting a new vulnerability site.

bioRxiv · Mar 28, 2022 · PreprintImmunology

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

A. Antanasijevic, L. M. Sewall, C. A. Cottrell, D. G. Carnathan, L. E. Jimenez, J. T. Ngo, J. B. Silverman, B. Groschel, E. Georgeson, J. Bhiman, R. Bastidas, C. LaBranche, J. D. Allen, J. Copps, H. R. Perrett, , A. B. Ward

The paper uses cryoEM to analyze polyclonal antibody responses to HIV Env immunogens in rhesus macaques, revealing structural differences in antibody binding and immunogenicity of engineered mutations and glycan sites.

bioRxiv · Jan 28, 2021Immunology