Author

S. Gracias

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

N. Jouvenet· 5 shared F. Tangy· 2 shared G. Beauclair· 2 shared J. Richardson· 2 shared M. Chazal· 2 shared M. Lemasson· 2 shared M. Sourisseau· 2 shared Y. Unterfinger· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersMicrobiology

N. Jouvenet

Mutual co-authors in cluster

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6 papers

Recent·Most cited

In vitro phenotypic susceptibility of HIV-1 non-group M to CCR5 inhibitor (Maraviroc): TROPI-CO study

S. GRACIAS, I. El Yaalaoui, B. Visseaux, C. charpentier, D. Diane, C. Martin, F. Lermechain, J.-C. Plantier, E. Alessandri-Gradt

This study evaluates the phenotypic susceptibility of HIV-1 non-group M strains to Maraviroc, showing variability linked to tropism and highlighting the need for additional parameters beyond IC50 values.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2

S. Gracias, M. Chazal, A. Decombe, Y. Unterfinger, A. Sogues, L. Pruvost, V. Robert, S. Lacour, M. Lemasson, M. Sourisseau, Z. Li, J. Richardson, E. Decroly, S. Pellegrini, V. Caval, N. Jouvenet

This study identifies a mechanism by which tick-borne flaviviruses inhibit interferon signaling by targeting TYK2 catalytic activity through their NS5 protein.

bioRxiv · Sep 7, 2023Microbiology

Integrated protein-protein interaction and RNA interference screens reveal novel restriction and dependency factors for a tick-borne flavivirus in its human host

M. Sourisseau, Y. Unterfinger, M. Lemasson, M. Chazal, S. Gracias, G. Caignard, F. Piumi, A. Grot, S. Moutailler, D. Vitour, N. Jouvenet, M. Coulpier, S. A. Lacour, J. Richardson

The paper identifies novel host proteins interacting with TBEV and characterizes their role as dependency or restriction factors using PPI screens and RNAi.

bioRxiv · Nov 3, 2022 · PreprintMicrobiology

The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses

B. Bonaventure, A. Rebendenne, F. Garcia de Gracia, J. McKellar, S. Gracias, E. Labaronne, M. Tauziet, A. L. Chaves Valadao, E. Bernard, L. Briant, N. Gros, W. Djilli, M. Arnaud-Arnould, V. Courgnaud, H. Parrinello, , C. Goujon

This study identifies DDX42 as an intrinsic antiviral inhibitor that restricts HIV-1 and other positive-strand RNA viruses but not negative-strand RNA viruses.

bioRxiv · Oct 28, 2020Microbiology

RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to Yellow fever virus

G. Beauclair, F. Streicher, D. Bruni, S. Gracias, S. Bourgeau, L. Sinigaglia, T. Fujita, E. F. Meurs, F. Tangy, n. jouvenet

This study identifies RIG-I and PKR as key mediators of the pro-inflammatory response to YFV in hepatocytes, showing that stress granules are not required for cytokine induction.

bioRxiv · Feb 5, 2020Microbiology

Midgut barriers prevent the replication and dissemination of the yellow fever vaccine in Aedes aegypti

L. Danet, G. Beauclair, M. Berthet, G. Moratorio, S. Gracias, F. Tangy, V. Choumet, n. jouvenet

This study shows that YFV-17D replicates inefficiently in Aedes aegypti midgut and fails to disseminate, unlike a clinical isolate, due to midgut barriers.

bioRxiv · Mar 13, 2019Microbiology