T. Fujita

Modeling dry eye with an air-liquid interface in corneal epithelium-on-a-chip

This study modifies a corneal epithelium-on-a-chip model to simulate dry eye syndrome by applying an air-liquid interface stimulus and assesses its effects with and without diclofenac.

Early Differentiation Signatures in Human Induced Pluripotent Stem Cells Determined by Non-Targeted Metabolomics Analysis

This study uses non-targeted metabolomics to identify early differentiation signatures in hiPSCs during ectodermal lineage commitment, showing changes in metabolites like pyruvic acid and kynurenine.

Three-dimensional visualization of moss rhizoid system by refraction-contrast X-ray micro-computed tomography

This study visualizes and quantitatively analyzes the 3D rhizoid system of moss using X-ray micro-CT and machine learning, revealing its dense structure similar to vascular plant roots.

Development of a new 3D tracking system for multiple marmosets under free-moving conditions

This paper develops a 3D tracking system for multiple marmosets to analyze long-term social interactions and behavioral changes.

RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to Yellow fever virus

This study identifies RIG-I and PKR as key mediators of the pro-inflammatory response to YFV in hepatocytes, showing that stress granules are not required for cytokine induction.

CLEC-2 suppresses calcification in cultured osteoblasts

This study investigates the role of CLEC-2 and podoplanin in osteoblast calcification, finding that CLEC-2 suppresses calcification in cultured osteoblasts.

Ubiquitin-dependent and -independent roles of E3 ligase RIPLET in innate immunity

RIPLET functions as a molecular glue to assemble signaling scaffolds for the antiviral innate immune receptor RIG-I.

Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice

This study investigates the role of LTB4-BLT1 signaling in kidney fibrosis after unilateral ureteral obstruction in mice, finding that BLT1 inhibition reduces fibrosis markers.

Transgenic mouse lines expressing the 3xFLAG-dCas9 protein for enChIP analysis

The paper develops transgenic mice expressing 3xFLAG-dCas9 for enChIP analysis in primary CD4+ T cells, achieving high yields of targeted genomic region purification.