G. Wutz

Cohesin supercoils DNA during loop extrusion

This study shows cohesin supercoils DNA during loop extrusion, influencing genome architecture through both looping and supercoiling.

Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

This study shows cohesin uses distinct mechanisms for DNA loop extrusion and sister chromatid cohesion, and that CTCF boundary interactions may rely on related mechanisms.

CTCF is a DNA-tension-dependent barrier to cohesin-mediated DNA loop extrusion

The paper shows CTCF blocks cohesin-mediated DNA loop extrusion and regulates its direction and loop size, revealing it as an active regulator rather than a passive barrier.

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

The paper shows that ESCO1 and CTCF protect cohesinSTAG1 from WAPL, enabling long chromatin loops that persist during G1-phase.

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

The paper identifies a synthetic lethal relationship between STAG1 and STAG2 in cancers, showing STAG1 inactivation selectively targets STAG2-mutated cancer cells.