S. Liu

This study identifies D-AS2 as a noncoding RNA that promotes chemoresistance in SCC by activating YAP signaling through the PLD/PA axis, and shows that targeting D-AS2 sensitizes SCC to cisplatin.

This study investigates DNA methylation inheritance in Pacific oysters, finding that half of parental methylation differences are passed to offspring and revealing sex-specific methylation patterns linked to Rho signaling.

This study identifies acetylation as a regulatory mechanism in antibiotic resistance in E. coli, showing it negatively affects metabolism but positively influences motility, with PykF acetylation playing a key role.

This study examines the role of MMP12 and Calpain 1/2 in liver fibrosis resolution using a mouse model, finding that MMP12 inhibition delays resolution and Calpains may contribute to protein degradation.

The paper determines the structure of the ankyrin complex on human red blood cells and elucidates its assembly mechanism and role in mechanical stability.

This study shows that the Omicron variant of SARS-CoV-2 causes milder disease and lower viral load in mice, likely due to mutations outside the spike protein that block post-entry processes.

This study compares Reelin+ HSCs and Desmin+ HSCs in liver fibrosis using fate tracing, showing differences in activation, migration, and proliferation in response to cholestatic and hepatotoxic injuries.

This study shows that Sox2 forms DNA condensates that exert mechanical forces up to 7 pN, but chromatin nucleosomes reduce this force by sequestering Sox2.

This paper improves robot-assisted TMS by implementing inside-out tracking and projection mapping for better coil placement accuracy.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

This study shows that micronuclei can cause heritable transcriptional changes by disrupting chromatin states, even after chromosomes are reincorporated into normal nuclei.

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

OPEN leaf is an open-source cloud-based phenotyping system for tracking dynamic leaf-specific changes in Arabidopsis, demonstrating the utility of VIS sensors in high-throughput screens.

This study identifies CFAP61 as essential for sperm flagellum formation and male fertility in humans and mice, showing its role in axoneme stabilization and its mutation causing infertility.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

This study identifies miR-99 and ROR as regulators of neutrophil migration and anti-microbial defense in zebrafish.

The paper shows that TMYX slows pacemaker cell rate by antagonizing cAMP-induced modulation of f-channels, similar to muscarinic stimulation or beta-blockers, but without affecting overall cAMP levels.

This study identifies gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis, finding that vancomycin treatment promotes bacteria that induce regulatory T cells and ameliorate disease.

The paper shows oversized cells increase proteasome-mediated protein degradation to maintain size homeostasis by reducing growth efficiency.

This study analyzes structure-activity relationships of mitochondria-targeted tetrapeptides, finding that side chain composition and sequence register significantly affect their efficacy and membrane interactions.

This paper develops a stable cell clone system harboring self-replicating SARS-CoV-2 RNAs for drug screening, identifying three novel antiviral compounds.

This study investigates the mechanism by which TMPyP4 induces unfolding of RNA G-quadruplexes using simulations and experiments, revealing a two-state interaction mechanism.

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

This paper introduces Dynamic Cell Imaging (DCI) to study dynamic organelle movements in diatoms under environmental stress, finding lipid droplets as major active sites.

The paper uses single-molecule FRET to show SWR1 unwraps DNA and exchanges H2A-H2B for H2A.Z-H2B with timed precision.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This study identifies a β-catenin-NFκB-CFTR interactome in cholangiocytes that regulates inflammation and fibrosis during ductular reaction in liver disease.