Author

X. S. Xie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9 Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 10 Organism:human· 7 Assay:proteomics· 7 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

Y. Wang· 11 shared A. Yisimayi· 9 shared F. Jian· 8 shared F. Shao· 8 shared J. Wang· 8 shared R. Jin· 8 shared T. Xiao· 8 shared W. Song· 8 shared

Activity by Year

2019-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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11 shared papersImmunology

Y. Wang

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

A. Yisimayi, W. Song, J. Wang, F. Jian, Y. Yu, X. Chen, Y. Xu, S. Yang, X. Niu, T. Xiao, J. Wang, L. Zhao, H. Sun, R. An, N. Zhang, , Y. Cao

This study shows repeated Omicron exposures reduce immune imprinting from wildtype vaccines, leading to higher neutralizing antibodies against XBB variants.

Nature · Nov 22, 2023Peer-reviewedImmunology

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

Y. Cao, F. Jian, J. Wang, Y. Yu, W. Song, A. Yisimayi, J. Wang, R. An, X. Chen, N. Zhang, Y. Wang, P. Wang, L. Zhao, H. Sun, L. Yu, , X. S. Xie

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

bioRxiv · Sep 15, 2022Immunology

Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants

F. Jian, Y. Yu, W. Song, A. Yisimayi, L. Yu, Y. Gao, N. Zhang, Y. Wang, F. Shao, X. Hao, Y. Xu, R. Jin, Y. Wang, X. S. Xie, Y. Cao

This study shows that BA.4.6, BA.4.7, and BA.5.9 subvariants with R346 mutations evade humoral immunity more effectively than BA.4/BA.5, reducing neutralization titers by 1.5-2.6-fold.

bioRxiv · Aug 9, 2022Immunology

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

Y. R. Cao, F. Jian, Z. Zhang, A. Yisimayi, X. Hao, L. Bao, F. Yuan, Y. Yu, S. Du, J. Wang, T. Xiao, W. Song, Y. Zhang, P. Liu, R. An, , X. S. Xie

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

bioRxiv · Aug 3, 2022Immunology

Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75

Y. Cao, W. Song, L. Wang, P. Liu, C. Yue, F. Jian, Y. Yu, A. Yisimayi, P. Wang, Y. Wang, Q. Zhu, J. Deng, W. Fu, L. Yu, N. Zhang, , X. Wang

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

bioRxiv · Jul 18, 2022Immunology

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

Y. R. Cao, A. Yisimayi, F. Jian, W. Song, T. Xiao, L. Wang, S. Du, J. Wang, Q. Li, X. Chen, Y. Yu, P. Wang, Z. Zhang, P. Liu, R. An, , X. S. Xie

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

bioRxiv · Apr 30, 2022Immunology

Omicron BA.2 specifically evades broad sarbecovirus neutralizing antibodies

Y. Cao, A. Yisimayi, F. Jian, T. Xiao, W. Song, J. Wang, S. Du, Z. Zhang, P. Liu, X. Hao, Q. Li, X. Chen, L. Wang, P. Wang, R. An, , X. S. Xie

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

bioRxiv · Feb 7, 2022 · PreprintImmunology

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

Z. Cui, P. Liu, N. Wang, L. Wang, K. Fan, Q. Zhu, K. Wang, R. Chen, R. Feng, Z. Jia, M. Yang, B. Zhu, W. Fu, T. Chu, L. Feng, , X. Wang

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

bioRxiv · Dec 29, 2021 · PreprintBiophysics

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Y. R. Cao, J. Wang, F. Jian, T. Xiao, W. Song, A. Yisimayi, W. Huang, Q. Li, P. Wang, R. An, J. Wang, Y. Wang, X. Niu, S. Yang, H. Liang, , X. S. Xie

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

bioRxiv · Dec 7, 2021Immunology

Protein and Lipid Mass Concentration Measurement in Tissues by Stimulated Raman Scattering Microscopy

S. Oh, C. Lee, W. Yang, A. Li, C. Ran, W. Yin, C. J. Tabin, D. Fu, X. S. Xie, M. W. Kirschner

The paper introduces NoRI, a SRS microscopy method to measure protein, lipid, and water concentrations in tissues, showing cell-specific variations and disease-related changes in Alzheimer's models.

bioRxiv · Sep 15, 2021Bioengineering

Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants

S. Du, P. Liu, Z. Zhang, T. Xiao, A. Yasimayi, W. Huang, Y. Wang, Y. R. Cao, X. S. Xie, J. Xiao

This study identifies two potent monoclonal antibodies against the B.1.351 variant and shows their efficacy against other variants, suggesting their use as an antibody cocktail.

bioRxiv · Jul 30, 2021Biochemistry

Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

L. Qu, Z. Yi, Y. Shen, L. Lin, F. Chen, Y. Xu, Z. Wu, H. Tang, X. Zhang, F. Tian, C. Wang, X. Xiao, X. Dong, L. Guo, S. Lu, , W. Wei

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

bioRxiv · Mar 16, 2021Immunology

CTCF-mediated Chromatin Structures Dictate the Spatio-temporal Propagation of Replication Foci

Q. P. Su, Z. W. Zhao, L. Meng, M. Ding, W. Zhang, Y. Li, M. Liu, R. Li, Y.-Q. Gao, X. S. Xie, Y. Sun

The paper visualizes replication foci during S-phase and reveals a CTCF-dependent hierarchical radial propagation pattern that reverses directionality over time.

bioRxiv · Jan 21, 2019Cell Biology