S. Liu

This study identifies acetylation of the fungal effector FolSvp1 as critical for its stability and virulence in tomato plants.

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

This study predicts microbiota responses to environmental pH and osmolality by analyzing bacterial growth under controlled conditions and identifying predictive genes and pathways.

This study investigates the evolutionary conservation of m6A-related genes in insects and identifies METTL3's role in silkworm embryonic development through functional analysis.

This study identifies PDK4-dependent hypercatabolism in senescent cells that creates an acidic microenvironment, promoting cancer resistance and age-related pathologies.

This study uses a near atomistic model to show that chromatin fibers break into clutches and trimers/tetramers under tension, supporting a hypothesis of in vivo chromatin configurations as folding intermediates.

The paper identifies 'active bulging' as a process that promotes biofilm formation in bacterial swarms through liquid bulge formation and cell density manipulation.

The paper reconstructs the evolutionary history of root-nodule symbiosis in the nitrogen-fixing clade, identifying a two-step process involving shifts in evolutionary lability that explain multiple independent gains and losses of the trait.

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

This paper introduces ACES, absorbable conductive scaffolds that enhance peripheral nerve regeneration and stimulation in animal models.

This study uses MINFLUX to track motor protein stepping in living cells and resolve their spatial organization on microtubules.

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

This study shows that nutrient limitation increases malaria parasite tolerance to the drug dihydroartemisinin, mimicking genetic resistance mechanisms.

This study identifies HCP5 as a key antiapoptotic factor in ESCC by preventing UTP3 degradation and activating c-Myc to suppress apoptosis.

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.

This study uses iterative transcription factor screening to generate microglia-like cells from human iPSCs, identifying a combination of TFs that efficiently differentiate iPSCs into microglia-like cells within 4 days.

This study characterizes the entry mechanisms and antibody neutralization resistance of Omicron variants BA.1, BA.1.1, BA.2, and BA.3 compared to the D614G strain.

This paper identifies a new class of TEAD-YAP inhibitors with a novel binding mode that suppresses transcriptional activity and shows anti-proliferative effects in cancer cells.

MADET is a manually curated database that compiles 453 microbiota-drug associations from 24 papers to aid in understanding microbiota's role in anticancer drug efficacy and toxicity.

This study identifies self-organized canals in bacterial colonies that enable long-range directed transport of cells and vesicles, driven by biosurfactant-mediated fluid flows.

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.

The paper compares exercise and antioxidant intervention in type 2 diabetic rats, showing both improve blood glucose via hepatic AMPK activation and redox balance, with exercise promoting moderate ROS for AMPK activation.

This study shows EGCG protects against radiation-induced intestinal injury by preserving macrophages and gut microbiota, reducing inflammation and improving survival in mice.

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

The paper shows that hypoxia induced by pinewood nematode (PWN) loading increases tracheal elasticity and ECM thickness in beetles, enhancing PWN transmission.

This study identifies endothelial cell Wnt2 and Wnt9b as key regulators of liver zonation and repair, showing their therapeutic potential in acute liver failure using single-cell spatial transcriptomics.

This study shows that M2 macrophage-derived extracellular vesicles reduce cytokine storm by targeting multiple pathways and can act as nanodecoys against SARS-CoV-2.

The paper shows that thyroid hormone induces BAFF overexpression, leading to abnormal B cell differentiation in Graves disease.

This study identifies alnustone as a drug that inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A, reducing biofilm formation and protecting against infection.