Author

S. O'Rahilly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Biochemistry· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

A. P. Coll· 3 shared D. B. Savage· 3 shared D. Rimmington· 3 shared G. S. H. Yeo· 3 shared S. Patel· 3 shared S. Virtue· 3 shared Y. C. L. Tung· 3 shared A. Alvarez-Guaita· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersPhysiology

A. P. Coll

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Author profile →

7 papers

Recent·Most cited

Longitudinal profiling of the pregnancy plasma proteome through organic solvent precipitation and nano LC-MS/MS

A. L. George, E. Cook, G. C. S. Smith, S. D. Charnock-Jones, S. O'Rahilly, F. Reimann, F. M. Gribble, R. G. Kay

This study profiles the pregnancy plasma proteome using a novel precipitation method, identifying 433 protein groups with tissue-specific associations and changes during gestation.

bioRxiv · Dec 11, 2023 · PreprintBiochemistry

Loss of Mfn1 but not Mfn2 enhances adipogenesis

J. P. Mann, L. Tabara, A. Alvarez-Guaita, L. Dong, A. Haider, K. Lim, P. Tandon, J. E. Minchin, S. O'Rahilly, S. Patel, D. J. Fazakerley, J. Prudent, R. K. Semple, D. B. Savage

The paper shows that loss of Mfn1 promotes adipogenesis in cultured cells, while loss of Mfn2 does not, indicating distinct roles for Mfn1 and Mfn2 in adipocyte differentiation.

bioRxiv · Nov 4, 2022 · PreprintCell Biology

GDF15 antagonism limits severe heart failure and prevents cardiac cachexia in mice

M. Takaoka, J. A. Tadross, A. Al-Hadithi, R. Villena-Gutierrez, J. Tromp, S. Absar, M. Au, J. Harrison, A. P. Coll, S. J. Marciniak, D. Rimmington, E. Oliver, B. Ibanez, A. A. Voors, S. O'Rahilly, , J. C. Goodall

This study shows that blocking GDF15 reduces severe heart failure and cardiac cachexia in mice by preventing weight loss and slowing disease progression.

bioRxiv · Sep 6, 2022Pathology

Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese mice.

S. Patel, A. Haider, A. Alvarez-Guaita, G. Bidault, J. S. El-Sayed Moustafa, E. Guiu-Jurado, J. A. Tadross, J. Warner, J. Harrison, S. Virtue, F. Scurria, I. Zvetkova, M. Blüher, K. S. Small, S. O'Rahilly, D. B. Savage

This study shows that GDF15 and FGF21, secreted by the liver in obese mice, reduce hepatic steatosis and insulin resistance when both are active.

bioRxiv · Jun 8, 2022 · PreprintPhysiology

A multi-component screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes

J. Chalmers, Y. C. L. Tung, C.-H. Liu, C. O'Kane, S. O'Rahilly, G. S. H. Yeo

The paper develops a Drosophila screening system to study mammalian appetite-related genes and identifies 16 and 10 genes affecting feeding behavior or nutrient status from GWAS and hypothalamic gene sets.

bioRxiv · May 4, 2020Physiology

GDF15 and the beneficial actions of metformin in pre-diabetes

A. P. Coll, M. Chen, P. Taskar, D. Rimmington, S. Patel, J. Tadross, I. Cimino, M. Yang, P. Welsh, S. Virtue, D. A. Goldspink, E. Miedzybrodzka, Y. C. L. Tung, S. Rodriguez-Cuenca, R. A. Tomaz, , S. O'Rahilly

This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.

bioRxiv · Jun 21, 2019Physiology

Loss And Gain Of Function Experiments Implicate TMEM18 As A Mediator Of The Strong Association Between Genetic Variants At Human Chromosome 2p25.3 And Obesity

R. Larder, M. F. M. Sim, P. Gulati, R. Antrobus, Y. C. L. Tung, D. Rimmington, E. Ayuso, J. Polex-Wolf, B. Y. H. Lam, C. Dias, D. W. Logan, S. Virtue, F. Bosch, G. S. H. Yeo, V. Saudek, , A. P. Coll

The paper identifies TMEM18 as a mediator of genetic variants at 2p25.3 associated with obesity through loss and gain of function experiments in mice.

bioRxiv · Mar 31, 2017Physiology