Author

S. S. Qamar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

P. St George-Hyslop· 4 shared D. Qian· 2 shared G. Krainer· 2 shared J. Nixon-Abell· 2 shared N. A. Erkamp· 2 shared T. J. Welsh· 2 shared T. Knowles· 2 shared A. A. Hyman· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBiophysics

P. St George-Hyslop

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Author profile →

4 papers

Recent·Most cited

Quantifying collective interactions in biomolecular phase separation

H. Ausserwoeger, D. Qian, G. Krainer, E. de Csillery, T. J. Welsh, T. Sneideris, T. M. Franzmann, S. S. Qamar, N. A. Erkamp, J. Nixon-Abell, M. Kar, P. St George-Hyslop, A. A. Hyman, S. Alberti, R. V. Pappu, T. P. J. Knowles

This study quantifies collective interactions in biomolecular phase separation by analyzing dilute phase concentrations and free energy, revealing how salts and small molecules modulate condensate formation.

bioRxiv · May 31, 2023Biophysics

Solid/liquid coexistence during aging of FUS condensates

Y. Shen, A. Chen, W. Wang, Y. Shen, F. S. Ruggeri, S. Aime, Z. Wang, S. S. Qamar, J. R. Espinosa, A. Garaizar Suarez, P. St George-Hyslop, R. Collepardo-Guevara, D. Weitz, D. Vigolo, T. Knowles

The paper shows that FUS condensates during aging exhibit solid/liquid coexistence, with the transition initiated at the interface between dense and dilute phases.

bioRxiv · Aug 15, 2022Biophysics

Tie-lines reveal interactions driving heteromolecular condensate formation

D. Qian, T. J. Welsh, N. A. Erkamp, S. S. Qamar, J. Nixon-Abell, G. Krainer, P. St George-Hyslop, T. Michaels, T. Knowles

The paper develops a method to determine tie-line gradients in ternary LLPS systems using dilute phase concentration measurements, revealing interaction types and compositions in biomolecular condensates.

bioRxiv · Feb 22, 2022 · PreprintBiophysics

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer's R47H mutant does the opposite

A. Vilalta, Y. Zhou, J. Sevalle, J. K. Griffin, K. Sato, D. H. Allendorf, S. De, M. Puigdellivol, A. Bruzas, M. A. Burguillos, R. B. Dodd, F. Chen, Y. Zhang, P. Flagmeier, L.-M. Needham, , G. C. Brown

The paper shows wild-type sTREM2 inhibits Aβ aggregation and neurotoxicity, while the R47H variant promotes Aβ aggregation and neurotoxicity.

bioRxiv · Dec 3, 2020Biochemistry