Author

Sam Drake

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Developmental Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Assay:protein structure· 1

Frequent Co-Authors

Arthur Jeremy WillseyiD· 4 shared Nawei SuniD· 4 shared Belinda WangiD· 3 shared Helen Rankin WillseyiD· 3 shared Matthew W. StateiD· 3 shared Vanessa DruryiD· 3 shared Yefim ZaltsmaniD· 3 shared Ethel Bader· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersSystems Biology

Arthur Jeremy WillseyORCID

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4 papers

Recent·Most cited

Autism genes converge on microtubule biology and RNA-binding proteins during excitatory neurogenesis

Nawei Sun, Noam Teyssier, Belinda Wang, Sam Drake, Meghan Seyler, Yefim Zaltsman, Amanda Everitt, Nia Teerikorpi, Helen Rankin Willsey, Hani Goodarzi, Ruilin Tian, Martin Kampmann, Arthur Jeremy Willsey

The paper represses 87 high-confidence ASD genes in a human cortical neurogenesis model, identifying 17 genes that disrupt developmental trajectory and reveal convergence on microtubule biology and RNA-binding proteins.

bioRxiv · Dec 22, 2023 · PreprintSystems Biology

A foundational atlas of autism protein interactions reveals molecular convergence

Belinda Wang, Rasika S. Vartak, Yefim Zaltsman, Zun Zar Chi Naing, Kelsey M. Hennick, Benjamin J. Polacco, Ali Bashir, Manon Eckhardt, Mehdi Bouhaddou, Jiewei Xu, Nawei Sun, Micaela C. Lasser, Yuan M. Zhou, Justin McKetney, Keelan Z. Guiley, , Nevan J. Krogan

The paper constructs a PPI network of 100 high-confidence ASD genes, identifies novel interactions, and uses AlphaFold-Multimer to prioritize variants for functional validation in organoids.

bioRxiv · Dec 3, 2023 · PreprintSystems Biology

Pleiotropy of autism-associated chromatin regulators

Micaela C. Lasser, Nawei Sun, Yuxiao Xu, Sheng Wang, Sam Drake, Karen Law, Silvano Gonzalez, Belinda Wang, Vanessa Drury, Octavio Castillo, Yefim Zaltsman, Jeanselle Dea, Ethel Bader, Kate E. McCluskey, Matthew W. State, , Helen Rankin Willsey

The paper investigates the role of chromatin regulators in autism spectrum disorder (ASD) by examining their involvement in microtubule biology and cellular proliferation, finding that ASD risk genes affect these processes and are enriched among microtubule-associated proteins.

Development · Jun 27, 2023Peer-reviewedDevelopmental Biology

Rare Maternally Inherited Coding Variants on Chromosome X Carry Predominantly Male Risk in Autism, Tourette Syndrome, and Attention-deficit/Hyperactivity Disorder

Sheng Wang, Belinda Lei Wang, Vanessa Drury, Sam Drake, Nawei Sun, Hasan Alkhairo, Juan Arbelaez, Clif Duhn, Tourette International Collaborative Genetics (TIC Genetics), Vanessa Hus Bal, K. Langley, Joanna Martin, Jinchuan Xing, Gary A. Heiman, Jay A. Tischfield, , Arthur Jeremy Willsey

medRxiv · Sep 22, 2022 · PreprintGenetic & Genomic Medicine