Author

L. K. Yim

Koch Institute for Integrative Cancer Research At MITORCID 0000-0002-4068-7447Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Liaoyuan HU· 1 shared Abby Hau· 1 shared Allen P. LiuiD· 1 shared Alvin Wang· 1 shared Arundeep SinghiD· 1 shared Ashley Lin· 1 shared Audrey Tei· 1 shared Avery WangiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperSynthetic Biology

A. Liaoyuan HU

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2 papers

Recent·Most cited

Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer

Dig Bijay Mahat, Heena Kumra, Sarah A Castro, Emily Metcalf, Kim Bich Nguyen, Ryo Morisue, William W. Ho, Ivy X. Chen, Brandon Sullivan, L. K. Yim, Arundeep Singh, Jiayu Fu, Sean K. Waterton, Yu‐Chi Cheng, Sylvie Roberge, , Phillip A. Sharp

This study shows mutant p53R172H in pancreatic cancer enhances immunosuppressive chemokine Cxcl1 expression via enhancer activation, reducing immune checkpoint inhibitor efficacy.

Immunity · Jul 1, 2025Peer-reviewedCancer Biology

Recombinant expression of Proteorhodopsin and biofilm regulators in Escherichia coli for nanoparticle binding and removal in a wastewater treatment model

Justin Z. Yang, Yvonne Wei, Catherine Yeh, Florence Liou, William C. Chen, Dylan Lu, Christine Chen, Justin Pei, Candice Lee, Emily Chen, Ashley Lin, Paul Imbrogulio, Katie Chang, A. Liaoyuan HU, Jesse Kao, , Jude C. Clapper

This paper demonstrates the use of genetically modified Escherichia coli to bind and remove nanoparticles in wastewater treatment through Proteorhodopsin and biofilm production.

bioRxiv · Mar 23, 2018 · PreprintSynthetic Biology