Novel peptide targeting CXCR4 disrupt tumor-stroma crosstalk to eliminate migrating cancer stem cells
Kanishka Tiwary, Anton Lahusen, Syeda Inaas, Bastian Beitzinger, Roman Schmid, Mirja Harms, Stefanie Hauff, Frank Arnold, Karolin Walter, Sonia Alcalá, Stephan A. Hahn, Elisabeth Heßmann, Alexander Kleger, Ninel Azoitei, Thomas Theodor Werner Seufferlein, , Patrick Christian Hermann
This study identifies a CXCL12/CXCR4/BMI1 signaling axis that promotes metastasis in PDAC via tumor-stroma crosstalk and shows that JM#21, a CXCR4 inhibitor, suppresses miCSCs and enhances chemotherapy efficacy.
bioRxiv · Mar 3, 2025 · PreprintCancer Biology