Author

Mirja Harms

Universität UlmORCID 0000-0002-5460-5166Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jan MünchiD· 3 shared Elsa Sánchez‐GarcíaiD· 2 shared Alexander KlegeriD· 1 shared Andrea Gilg· 1 shared Andy ChevignéiD· 1 shared Anton LahuseniD· 1 shared Bastian BeitzingeriD· 1 shared Billy Michael Chelliah JebarajiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

Jan MünchORCID

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3 papers

Recent·Most cited

GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration

Dan Albers, Sofya Novikova, Julio Vieyto‐Nuñez, Yasser Almeida‐Hernández, Chiara Pastorio, Florian Klassen, Dana Weiss, Pascal von Maltitz, Janeni Jaikishan, Moumita Datta, Hassan Jumaa, Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer, Manish Kumar, Palash Chandra Maity, , Mirja Harms

This study shows GPR15LG binds CXCR4, enhancing CXCL12-induced signaling and promoting cell migration in immune and cancer cells.

Cell Communication and Signaling · May 20, 2025Peer-reviewedCell Biology

Novel peptide targeting CXCR4 disrupt tumor-stroma crosstalk to eliminate migrating cancer stem cells

Kanishka Tiwary, Anton Lahusen, Syeda Inaas, Bastian Beitzinger, Roman Schmid, Mirja Harms, Stefanie Hauff, Frank Arnold, Karolin Walter, Sonia Alcalá, Stephan A. Hahn, Elisabeth Heßmann, Alexander Kleger, Ninel Azoitei, Thomas Theodor Werner Seufferlein, , Patrick Christian Hermann

This study identifies a CXCL12/CXCR4/BMI1 signaling axis that promotes metastasis in PDAC via tumor-stroma crosstalk and shows that JM#21, a CXCR4 inhibitor, suppresses miCSCs and enhances chemotherapy efficacy.

bioRxiv · Mar 3, 2025 · PreprintCancer Biology

Biomolecular models of EPI-X4 binding to CXCR4 allow the rational optimization of peptides with therapeutic potential

Pandian Sokkar, Mirja Harms, Christina Martina Stürzel, Andrea Gilg, Gönül Kızılsavaş, Martina Raasholm, Nico Preising, Manfred Wagner, Ludger Ständker, Gilbert Weidinger, Jan Münch, Elsa Sánchez‐García

The paper investigates how EPI-X4 binds to CXCR4 using simulations and experiments, leading to the design of more potent and safer CXCR4 antagonists.

bioRxiv · Oct 23, 2020 · PreprintMolecular Biology