Author

T. Gonen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 24 Biophysics· 8 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 30 Research Focus:protein structure prediction· 18 Assay:cryo-EM· 13 Assay:electronic health records· 8 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Approach:microscopy & imaging analysis· 4 Research Focus:cell type annotation· 3

Frequent Co-Authors

J. Hattne· 15 shared M. W. Martynowycz· 14 shared J. Unge· 5 shared M. Martynowycz· 5 shared M. T. B. Clabbers· 5 shared B. L. Nannenga· 4 shared H.-T. Lei· 4 shared A. Shiriaeva· 3 shared

Activity by Year

2017-2023 · peak 10/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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15 shared papersBiochemistry

J. Hattne

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Author profile →

33 papers

Recent·Most cited

BiochemistrybioRxivMar 24, 2018

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

H.-T. Lei, J. Ma, S. Sanchez-Martinez, T. Gonen

The paper presents the crystal structure of SLC38A9 bound to arginine in the cytosol-open state, revealing the mechanism of amino acid sensing and its role in mTORC1 signaling.

DOI 10.1038/s41594-018-0072-2

zebrafishprotein structure

𝕏 PostBluesky

BiochemistrybioRxivFeb 1, 2018

Analysis of global and site-specific radiation damage in cryo-EM

J. Hattne, D. Shi, C. Glynn…·T. Gonen

The paper analyzes radiation damage in cryo-EM using MicroED, finding similar damage dynamics to X-ray crystallography, including metal ion perturbation and disulfide bond breaking.

DOI 10.1016/j.str.2018.03.021

cryo-EMexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivDec 30, 2017

MicroED Structures of HIV-1 Gag CTD-SP1 Reveal Binding Interactions with the Maturation Inhibitor Bevirimat

M. D. Purdy, D. Shi, J. Chrustowicz…·M. Yeager

The paper uses MicroED to determine the structure of HIV-1 Gag CTD-SP1 with bevirimat, revealing binding interactions that inform drug discovery.

DOI 10.1073/pnas.1806806115

structural biologyexperimental assay

𝕏 PostBluesky