Author

S. Dunachie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:mouse· 2

Frequent Co-Authors

B. Kronsteiner· 3 shared A. Clarke· 2 shared A. J. Mentzer· 2 shared D. Dong· 2 shared G. Liu· 2 shared G. Ogg· 2 shared J. C. Knight· 2 shared L. Turtle· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

B. Kronsteiner

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Gonadal androgens are associated with decreased type I interferon production by pDCs and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents

O. L. Sampson, C. Jay, E. Adland, A. Csala, N. Lim, S. M. Ebbrecht, L. C. Gilligan, A. E. Taylor, S. S. George, S. Longet, L. C. Jones, E. Barnes, J. Frater, P. Klenerman, S. Dunachie, , P. Goulder

The paper investigates how gonadal androgens affect type I interferon production by pDCs and IgG titres to BNT162b2 in adolescents co-vaccinated with LAIV.

bioRxiv · Aug 1, 2023 · PreprintImmunology

Asparagine availability controls B cell homeostasis

Y. F. Yazicioglu, E. Marin, K. Bentkowska, H. Andrew, R. Mitchell, Z. Y. Wong, J. Fergusson, M. Borsa, J. C. Johnstone, M. Ali, B. Kronsteiner, I. L. Furlani, J. I. MacRae, M. J. Devine, M. Coles, , A. Clarke

The paper shows asparagine metabolism is critical for B cell function and germinal centre homeostasis, with Asn deprivation impairing survival, proliferation, and immune responses.

bioRxiv · Apr 3, 2023Immunology

A whole blood intracellular cytokine assay optimised for field site studies demonstrates polyfunctionality of CD4+ T cells in acute scrub typhus

M. Inthawong, N. Pinthong, A. Thaiprakhong, T. Wangrangsimakul, P. Sunyakumthorn, J. Hill, P. Sonthayanon, D. H. Paris, S. Dunachie, B. Kronsteiner

This study optimizes a whole blood intracellular cytokine assay to assess polyfunctional CD4+ T cell responses in acute scrub typhus, demonstrating its utility in field settings with limited resources.

bioRxiv · Oct 28, 2022Immunology

Dynamic mitochondrial transcription and translation in B cells control germinal centre entry and lymphomagenesis

Y. F. Yazicioglu, E. M. Marin, C. Sandhu, S. Galiani, I. G. A. Raza, M. Ali, B. Kronsteiner, E. Compeer, M. Attar, S. Dunachie, M. Dustin, A. Clarke

This study shows that mitochondrial transcription and translation in B cells are critical for germinal centre entry and lymphomagenesis, with TFAM playing a key role.

bioRxiv · Jul 19, 2022 · PreprintImmunology

The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

T. I. de Silva, G. Liu, B. B. Lindsey, D. Dong, D. Shah, A. J. Mentzer, A. Angyal, R. Brown, M. D. Parker, Z. Yin, X. Yao, L. Turtle, S. Dunachie, COVID-19 Genomics UK (COG-UK) Consortium, M. K. Maini, , T. Dong

The paper identifies SARS-CoV-2 T-cell epitope variants that reduce recognition by T-cells, highlighting the risk of immune evasion.

bioRxiv · Apr 8, 2021Immunology

Co-evolutionary signals from Burkholderia pseudomallei genomics identify its survival strategies and highlight improving environmental health as prevention policy

C. Chewapreecha, J. Pensar, S. Chattagul, M. Pesonen, A. Sangphukieo, P. Boonklang, C. Potisap, S. Koosakulnirand, E. J. Feil, S. Dunachie, N. Chantratita, D. Limmathurotsakul, S. J. Peacock, N. P. J. Day, J. Parkhill, , J. Corander

This study identifies co-selected gene pairs in Burkholderia pseudomallei genomes that enhance survival under nutrient stress, linking environmental factors to melioidosis prevalence.

bioRxiv · Aug 11, 2020 · PreprintMicrobiology

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

T. Dong, Y. Peng, A. J. Mentzer, G. Liu, X. Yao, Z. Yin, D. Dong, W. Dejnirattisai, L. Turtle, T. Rostron, K. Subramaniam, P. Thomson, P. Zhang, C. Dold, J. Ratcliff, , Lopez-C

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

bioRxiv · Jun 5, 2020Immunology