C. Chiu

Proinsulin C-peptide is a major source of HLA-DQ8 restricted HIPs recognized by human Islet-Infiltrating CD4+ T cells

This study identifies 13 new proinsulin-derived HIPs recognized by human islet-infiltrating CD4+ T cells in T1D, highlighting proinsulin C-peptide's central role in HIP formation.

Development and validation of a respiratory syncytial virus multiplex immunoassay

The paper develops and validates a multiplex immunoassay for RSV antibodies, showing robust performance and subtype identification capability.

Pandemic, epidemic, endemic: B cell repertoire analysis reveals unique anti-viral responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

The paper analyzes B cell repertoires from SARS-CoV-2, Ebola, and RSV infections to identify distinct anti-viral immune responses and repertoire characteristics.

An intranasal ASO therapeutic targeting SARS-CoV-2

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

Composite modeling of leaf shape across shoots discriminates Vitis species better than individual leaves

The paper models leaf shape changes across shoots in Vitis species and finds composite leaves better predict species identity than individual leaves.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.

Diazotrophic bacteria from maize exhibit multifaceted plant growth promotion traits in multiple hosts

The paper identifies diazotrophic bacteria from Sierra Mixe maize that promote plant growth through multiple mechanisms in different host plants.

E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation and dynamics

This study shows TraR regulates transcription by altering RNAP conformation and dynamics, affecting promoter DNA interactions and transcription outcomes.

Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry

The paper shows that tibrovirus glycoproteins can enter human, bat, and nonhuman primate cells, but replication resistance varies among cell types.

A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection

The paper uses crowdsourced analysis of gene expression data to identify molecular signatures predictive of susceptibility to respiratory viruses before and after exposure.