Author

M. E. Polak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

A. F. Vallejo· 3 shared B. D. MacArthur· 2 shared J. West· 2 shared P. S. Stumpf· 2 shared S. Sirvent· 2 shared A. Al-Shamkhani· 1 shared A. Appios· 1 shared A. Vallejo· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

A. F. Vallejo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity

A. Appios, J. Davies, S. Sirvent, S. Henderson, S. Trzebanski, J. Schroth, M. L. Law, I. Boal Carvalho, H. Yuan-Hao Kan, S. Lovlekar, C. Major, A. Vallejo, N. J. Hall, M. Ardern-Jones, S. M. Henson, , C. L. Bennett

The paper investigates how monocyte differentiation in adult skin leads to Langerhans cell identity through intrinsic and extrinsic factors.

bioRxiv · Nov 13, 2023Immunology

Dual Dean entrainment with volume ratio modulation for efficient co-encapsulation: Extreme single-cell indexing

J. Harrington, L. B. Esteban, J. Butement, A. F. Vallejo, S. I. R. Lane, B. Sheth, M. S. A. Jongen, R. Parker, P. S. Stumpf, R. C. G. Smith, B. D. MacArthur, M. J. Rose-Zerilli, M. E. Polak, T. J. Underwood, J. West

This paper introduces Pirouette-seq, a method for efficient single-cell co-encapsulation with improved throughput and signal-to-noise ratio.

bioRxiv · Apr 8, 2021Cell Biology

Peptide:MHC dependent activation of natural killer cells through KIR2DS2 generates anti-tumor responses

P. Rettman, M. D. Blunt, B. Mbiribindi, R. Fulton, R. Schittenhelm, A. F. Vallejo, L. Bastidas-Legarda, M. E. Polak, R. Ayala, A. W. E. Purcell, A. Al-Shamkhani, C. Retiere, S. I. Khakoo

This study shows that activating NK cells via KIR2DS2 with a peptide:MHC vaccine generates anti-tumor responses and identifies XPO1 as a cancer-associated ligand for KIR2DS2.

bioRxiv · Apr 15, 2020 · PreprintImmunology

Genomic programming of antigen cross-presentation in IRF4-expressing human Langerhans cells

M. E. Polak, S. Sirvent, K. Clayton, J. D. Davies, A. F. Vallejo, Z. Wu, J. Woo, J. Riddell, P. S. Stumpf, M. Rose-Zerilli, J. West, M. Pujato, X. Chen, C. H. Woelk, B. D. MacArthur, , H. Singh

The paper identifies IRF4 as a key transcription factor driving antigen cross-presentation in human Langerhans cells, distinguishing them from conventional dendritic cells.

bioRxiv · Feb 5, 2019 · PreprintImmunology