Y. Pang

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

Clostridium ablates tumors by degrading collagen mesh andinducing ferroptosis

This paper describes a Clostridium strain that degrades collagen and induces ferroptosis in tumors, leading to effective tumor destruction in mice.

Evolutionary analysis of paired box gene family and biological function exploration of Lr.Pax7 in lamprey (Lethenteron reissneri)

This study identifies and analyzes Pax7 in lamprey, showing its potential ancestral role and functional similarities to higher vertebrates in metabolic and developmental processes.

SHRIMP: Genetically Encoded mScarlet-derived Red Fluorescent Hydrogen Peroxide Sensor with High Brightness and Minimal Photoactivation

This paper develops SHRIMP, a genetically encoded red fluorescent hydrogen peroxide sensor with high brightness and minimal photoactivation, validated in mammalian cells and primary islet tissue.

Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

Development, Characterization, and Structural Analysis of a Genetically Encoded Red Fluorescent Peroxynitrite Biosensor

The paper develops a red fluorescent peroxynitrite biosensor (pnRFP) using a genetically encoded boronic acid-containing amino acid, characterizes its properties, and elucidates its sensing mechanism through structural analysis.

Genetically Encoded Boronolectin as a Specific Red Fluorescent UDP-GlcNAc Biosensor

This paper develops a genetically encoded red fluorescent UDP-GlcNAc biosensor using a boronolectin and validates its function in live cells.

Defining ancestry, heritability and plasticity of cellular phenotypes in somatic evolution

The paper introduces PATH, a framework to quantify heritability and plasticity of cellular phenotypes in somatic evolution using single-cell data from mouse and human samples.

How do Vampires Suck Blood?

This study identifies two groups of metabolites in lamprey buccal glands that modulate host responses and establishes a spatial metabolomics database for lamprey research.

miR-148a-3p inhibits osteogenesis by targeting Itga11 via PI3K/Akt/GSK3/β-catenin pathway

On the origin of R2 orientation dependence angle offsets in white matter

The paper identifies the origin of R2 orientation dependence angle offsets in white matter and proposes a framework to better characterize anisotropic R2 using diffusion tensor data.

Development and optimization of a Barley stripe mosaic virus (BSMV)-mediated gene editing system to improve Fusarium head blight (FHB) resistance in wheat

This paper develops a BSMV-mediated gene editing system for wheat to improve FHB resistance by editing the Fhb1 gene without requiring transformation.

Orientation dependent proton transverse relaxation in the human brain white matter: The magic angle effect on a cylindrical helix

The paper introduces a new framework to model orientation-dependent proton transverse relaxation in human brain white matter, showing improved accuracy over existing models.

Variations in soil nutrient dynamics and bacterial communities in long-term tea monoculture production systems

This study examines how long-term tea monoculture affects soil nutrient dynamics and bacterial communities across different stand ages.

Genome sequencing and functional genes comparison between Sphingopyxis USTB-05 and Sphingomonas morindae NBD5

This study sequenced and compared the genomes of two Sphingomonadaceae strains, revealing shared lutein synthesis genes and unique genes for hepatotoxin degradation in Sphingopyxis USTB-05.

A water-reward task assay for evaluating mouse mutualistic cooperative behavior

This paper introduces a water-reward task assay to quantify mutualistic cooperative behavior in mice and provides detailed procedures for its implementation.

Rv3737 is required for Mycobacterium tuberculosis growth in vitro and in vivo and correlates with bacterial load and disease severity in human tuberculosis

A Mycobacterium tuberculosis effector protein attacks host innate immunity by acting as an unusual ubiquitinating enzyme

This paper shows that Mtb PknG acts as an unusual ubiquitinating enzyme by promoting ubiquitination of TRAF2 and TAK1 to suppress host innate immunity.

Specific gyrA gene mutations correlate with high prevalence of discordant levofloxacin resistance in Mycobacterium tuberculosis isolates from Beijing, China

The paper identifies specific gyrA gene mutations in Mycobacterium tuberculosis isolates that cause discordant levofloxacin resistance between molecular and phenotypic testing.