T. Xiao

The paper identifies the nucleus as a site for disposing of non-imported mitochondrial precursor proteins in yeast through proteasome-based quality control.

The study shows the GET pathway directs non-imported mitochondrial proteins to the ER, preventing toxicity and enabling their re-import via the ER-SURF pathway.

The paper characterizes glycosylation of SARS-CoV-2 Spike and ACE2 using glycomics and simulations to understand their interactions and guide immunogen design.

The paper reports two cryo-EM structures of the SARS-CoV-2 spike protein, showing prefusion and postfusion conformations, and discusses their implications for viral entry and immune evasion.

This study shows that mesenchymal stem cells can deliver oncolytic virotherapy to DIPG tumors, significantly improving survival when combined with radiotherapy in preclinical models.

The paper identifies key regulators of BRAF inhibitor resistance in melanoma using CRISPR screens and integrates multi-omics data to reveal CDK6-dependent mechanisms.

This study shows that fatty acids enter FABP via local unfolding of helix 2, not gap widening, using a gap-closed variant and biophysical experiments.

This study shows that CD8+ T-cells mediate immunoediting in murine gliomas, affecting genomic stability and immune evasion.

This paper shows that dopamine receptor 2 activation in glioblastoma cells increases their growth, stemness, and metabolic activity, suggesting dopamine signaling as a therapeutic target.