AlphaFold2-Guided Functional Screens Reveal a Conserved Antioxidant Protein at ER Membranes
Zhijian Ji, Henry De Belly, Taruna Pandey, Bingying Wang, Yao Tang, Jingxuan Yao, Shiya Xu, Kathy Li, Yanchang Bian, Shouhong Guang, Zhiyong Lou, Alma L. Burlingame, Orion David Weiner, Thomas D. Goddard, Dengke K. Ma
The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.
Cell Reports · Jun 1, 2026Peer-reviewedCell Biology