Tomoya S. Kitajima

Ex vivo live imaging unveils the dynamics of oocyte formation in mice

This study uses ex vivo live imaging to observe oocyte formation dynamics in mice, revealing blebbing activity during mitosis-to-meiosis transition and no organelle transfer between germ cells.

Kif11-haploinsufficient oocytes reveal spatially differential requirements for chromosome biorientation in the spindle

This study shows that Kif11 haploinsufficiency in mouse oocytes leads to impaired spindle bipolarization and spatially differential chromosome biorientation.

Kinetochores promote timely spindle bipolarization to prevent microtubule attachment errors in oocytes

The paper shows that kinetochores promote timely spindle bipolarization in mouse oocytes to reduce microtubule attachment errors and aneuploidy risk.

Transcriptomic Signatures of WNT-Driven Pathways and Granulosa Cell-Oocyte Interactions during Primordial Follicle Activation

This study uses single-cell RNA sequencing to analyze WNT signaling's role in granulosa cell-oocyte interactions during primordial follicle activation, revealing transcriptomic changes and their impact on fertility.

Comprehensive comparison of female germ cell development in vitro and in vivo identifies epigenetic gene regulation crucial for oocyte development and embryonic competence

Production of Offspring from Azoospermic Mice with Meiotic Failure: Precise Biparental Meiosis within Halved Oocytes

This study shows that reducing ooplasmic volume in oocytes improves meiotic accuracy and embryo development, enabling offspring production from azoospermic mice with spermatocyte arrest.