J. DeRisi

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

The paper develops a computational pipeline combining Rosetta and cryo-EM to analyze ACE2 receptor traps' binding to SARS-CoV-2 variants, showing high affinity and neutralization capabilities against Omicron and Delta.

Human sialomucin CD164 is an essential entry factor for lymphocytic choriomeningitis virus

This study identifies CD164 as an essential entry factor for LCMV in human cells and tissues, showing its role in viral infection and potential as a therapeutic target.

Naive arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigen

This study identifies a defect in anergy and a biased TCR repertoire in naive arthritogenic SKG CD4 T cells, driven by endogenous viral superantigens, leading to autoimmune arthritis.

Poecivirus is present in individuals with beak deformities in seven species of North American birds

This study detects Poecivirus in six avian species with beak deformities across Alaska and Maine, showing the virus is not restricted to Alaska and is present in individuals with AKD-like symptoms.

Inoculation by mosquito induces durable differences in serological profile in non-human primates infected with DENV1

This study compares serological profiles of DENV1-infected non-human primates inoculated by mosquito versus subcutaneous injection, finding durable differences in sero-reactivity at one year post-infection.

Zika virus alters centrosome organization to suppress the innate immune response

This study shows that Zika virus NS3 protein binds CEP63 to disrupt centrosome organization and suppress innate immune response by destabilizing TBK1.

Label-free imaging and classification of live P. falciparum

This paper demonstrates label-free microscopy with deep learning for accurate classification of Plasmodium falciparum life stages and parasitemia quantification, outperforming traditional methods.

Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries

This paper introduces SPD-NGS, a method using phage display libraries to deeply profile protease substrate specificity, identifying cleavage sites and natural substrates with high coverage and accuracy.

Rapid metagenomic characterization of a case of imported COVID-19 in Cambodia

The paper describes using metagenomic sequencing and an open-source pipeline to rapidly characterize Cambodia's first COVID-19 case.

Designing and implementing programmable depletion in sequencing libraries with DASHit

The paper introduces DASHit, a software tool that designs CRISPR-based depletion targets to reduce high-abundance sequences in sequencing libraries, demonstrating its effectiveness across three species.

Microbiome and Antimicrobial Resistance Gene Dynamics in International Travelers

This study uses metagenomic sequencing to track changes in gut microbiota and antimicrobial resistance genes in international travelers, finding increased resistance genes and Escherichia species without affecting microbial diversity.

A Fixed Moderate-dose Combination of Tiletamine+Zolazepam Outperforms Midazolam in Induction of Short-term Immobilization of Ball Pythons (Python regius)

This study compares the effectiveness of tiletamine+zolazepam and midazolam in anesthetizing ball pythons, finding that the combination provides more reliable immobilization.

Low-Cost Touchscreen Driven Programmable Dual Syringe Pump for Life Science Applications

The paper describes a low-cost, programmable dual syringe pump for life science applications, demonstrating its use in automated cell lysis.

Avian keratin disorder of Alaska black-capped chickadees is associated with Poecivirus infection

This study confirms a strong association between Poecivirus infection and avian keratin disorder in black-capped chickadees, showing Poecivirus replicates in beak tissue.