W. He

The paper shows that Her2 protein delivered via nanolipoprotein particles induces malignant transformation in non-malignant breast cells by altering transcriptome and activating downstream Her2 pathways.

The paper analyzes SARS-CoV-2 quasispecies structure using SMRT sequencing, revealing a One-King model with dominant and minor haplotypes and their evolutionary dynamics.

The paper reports the structure of SARS-CoV-2 main protease in the apo state at physiological pH, revealing its inactive conformation and structural differences from the active state.

This study shows that immunization with SARS-CoV-2 RBD elicits potent neutralizing antibodies without antibody-dependent enhancement in rodents.

This study investigates how TSG-6 affects BMP-4/Smad signaling and odonto/osteogenic differentiation of DPSCs in an inflammatory environment.

This study shows that longer double-stranded RNAs accumulate more in plastids, leading to stronger RNAi effects against Colorado potato beetle larvae.

This study shows CD155/CD96 promotes immunosuppression in LUAD by inhibiting antitumor immune responses and up-regulating CD96 in CD8 T cells, with potential therapeutic implications.

This study analyzes TCR repertoires in RA patients and identifies clonal expansion and shared repertoires between EMT and Th17 cells, correlating TCR diversity with disease activity.

This study characterizes LepΔI14/ΔI14 rats as a NASH model through long-term transcriptomic analysis, revealing unique disease progression and gene expression patterns.

This paper develops a method to directly synthesize EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells, achieving high labeling efficiency in both prokaryotic and eukaryotic cells.

This study shows Bclaf1 is degraded by alphaherpesvirus US3 and is critical for type I interferon signaling and antiviral immunity.

This paper introduces Hessian-SMLM, a method to reduce pixel-dependent readout noise in sCMOS cameras for single-molecule localization microscopy, improving imaging time resolution.