W. Xu

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.

This paper reprograms the endogenous CRISPR-Cas10 system in Mycobacterium tuberculosis for efficient gene editing, RNA interference, and genome-wide screening, enabling functional genomics studies and drug/vaccine development.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

The paper investigates how biochar affects nitrogen assimilation in cotton seedlings by analyzing gene expression and enzyme activity under different urea and biochar conditions.

This study characterizes a phage ferredoxin from Prochlorococcus marinus, showing structural similarity to cyanobacterial ferredoxins and functional electron transfer to a host sulfite reductase.

This paper identifies Apaf-1 pyroptosome as a machinery that senses mitochondrial permeability transition (MPT) and triggers pyroptosis via caspase-4/11 and GSDME.

The paper compares maize leaf microbiomes under drought and well-watered conditions using metagenomic sequencing to identify functional gene category differences.

This study shows that CTR9 loss in breast cancer cells increases H3K27me3 levels and switches PRC2 subtype, making cells more sensitive to PRC2 inhibitors.

This study identifies viral genetic integrations in gut microbes associated with microbial dysbiosis in colorectal carcinoma tumorigenesis.

This study shows BMP9 induces osteogenic differentiation in GC-1spg cells through upregulated markers and in vivo bone formation.

This study shows that longer double-stranded RNAs accumulate more in plastids, leading to stronger RNAi effects against Colorado potato beetle larvae.

This study analyzes metagenome-assembled genomes of Hydrothermarchaeota to reveal their versatile carbon and element cycling functions and community interactions in hydrothermal sediments.

The paper develops a DIVA strategy using epitope-containing short peptides (ECSPs) to differentiate vaccinated from infected animals, showing distinct IgG serodynamics that enable effective monitoring.

This study shows N-acetyl cysteine (NAC) alleviates Coxsackievirus B-induced myocarditis by inhibiting caspase-1 and viral proteases, offering a potential therapeutic option.

This study uses dental calculus to analyze the oral microbiome of wild mammals, revealing taxonomic, functional, and historical insights into microbiome evolution and host-pathogen interactions.

This study shows that the oncoprotein CoAA interacts with RNA polymerase II CTD repeats, explaining the functional requirement of diheptad repeats in transcription and alternative splicing.

This study shows that targeting glutamine metabolism in tumors reduces MDSC generation, increases inflammatory macrophages, and enhances anti-tumor immunity, making checkpoint-resistant tumors responsive to immunotherapy.

This study adapts base editors to Streptomyces, achieving high-efficiency genome editing without DNA double-strand breaks.

This study shows that the nurf-1 gene in C. elegans split into two isoforms, Yin and Yang, which have opposing roles in gametogenesis and led to the creation of two separate genes.

The paper identifies intronic heterochromatin as a mechanism suppressing cryptic transcription initiation by TEs in Arabidopsis.

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

This study introduces SLHC-seq, a new targeted sequencing method that improves detection of pancreatic cancer by analyzing short mutant cfDNA fragments, enabling earlier diagnosis.

TISMorph quantifies cell shape features like texture, irregularity, and spreading to classify osteosarcoma cell lines treated with cytoskeletal drugs.

This study shows that 4-methoxy-TEMPO reduces mycobacterial burden in zebrafish by targeting both host and bacterial redox mechanisms.

This study identifies BriC as a competence-induced gene in Streptococcus pneumoniae that promotes biofilm development and colonization, with its expression regulated by the ComE master regulator and showing genomic plasticity in some isolates.

This study compares glucose administration methods in Japanese flounder, showing different insulin and brain-gut peptide responses, and suggests a negative feedback mechanism in glucose homeostasis.