X. Yu

This study establishes a trans-resveratrol-induced mouse pulmonary fibrosis model and compares it to the bleomycin-induced model, finding it causes less damage and progresses more slowly.

This paper introduces an accelerated SWATH MS method for protein biomarker discovery in FFPE tissues, showing reduced instrument time and batch effects while maintaining good protein quantification and clinical separation.

This study characterizes carbapenem-resistant Klebsiella pneumoniae isolates, identifying ST11 as the main type and blaKPC-2 as the dominant carbapenemase gene.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

The paper shows that long-term potentiation increases extrasynaptic exocytosis of GluN2A-containing NMDA receptors, primarily controlled by SNAP-23.

This study shows β-blockers like carvedilol can activate β2AR at low concentrations, enhancing L-type Ca2+ channel activity in neurons through localized cAMP/PKA signaling.

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

The paper develops a method to estimate immune cell content in tumors using scRNA-seq reference data, showing improved performance over existing methods in distinguishing immune subtypes.

This study presents cryo-EM structures of the human glutamine transporter SLC1A5 in an outward-facing conformation, revealing insights into its transport mechanism and substrate recognition.

This study identifies TGF-β1 signaling's role in chromatin remodeling that drives glycolysis in pathogenic TH17 cells through epigenetic regulation of metabolic regulators.

The paper determines the cryo-EM structure of the FXN-bound active human ISC biosynthesis complex, revealing how FXN activates NFS1 by removing zinc inhibition and stabilizing protein interfaces.

This study investigates the antimycobacterial mechanism of FP-11g, a fluoroquinophenoxazine compound, and identifies resistance mechanisms in Mycobacterium smegmatis.

The paper shows that community function in microbial communities saturates with diversity, with no net change in function beyond 20 taxa.

This study shows FGF21 reduces melanogenesis in alpaca melanocytes by activating ERK1/2 and downregulating MITF, leading to decreased melanin production.