X. Yu

The paper identifies Olfr109 as an olfactory receptor that detects insulin peptides in pancreatic β cells, modulating glucose metabolism and inflammation.

This paper demonstrates that Ac5GalNTGc is a potent inhibitor of O-glycan biosynthesis, effectively reducing O-glycan elongation and modulating leukocyte functions.

This paper optimizes human intestinal enteroid culture conditions to enhance cultivation of diverse human norovirus strains and improves replication consistency over time.

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

The paper investigates photosynthesis-related gene expression in albino Artocarpus heterophyllus seedlings, finding down-regulated genes in pigment synthesis and photosynthesis pathways.

This study shows that blocking N- and O-glycan biosynthesis reduces SARS-CoV-2 viral entry by affecting Spike protein proteolysis and RBD presentation.

This paper introduces a simplified agarose microbead-based SiMPull method that is faster, easier, and more reproducible than the original technique while maintaining similar sensitivity and signal-to-noise ratio.

This study identifies how PTP-MEG2 regulates exocytosis by dephosphorylating specific sites on NSF, DYNAMIN2, and MUNC18-1, revealing distinct structural mechanisms for substrate recognition.

This study identifies Dhx36 as essential for skeletal muscle stem cell regeneration by regulating mRNA translation through binding and unwinding 5' UTR G-quadruplex structures.

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

This study examines the expression of ACE2, TMPRSS2, and CTSL in human airway epithelial cells under various physiological and pathological conditions and finds associations with SARS-CoV-2 infection risk.

This paper develops a thermodynamic model to analyze how p53 mutations affect zinc binding and stability, showing that synthetic zinc metallochaperones can reactivate diverse p53 mutants.

This study uses transcriptomics to resolve the phylogenetic relationships of Odonata, finding monophyletic damselfly and dragonfly families and estimating their origins in the late Triassic.

The paper shows HOXB13 expression is reduced or lost in neuroendocrine prostate cancer (NEPCa) and that NEPCa tumors lose prostate-specific HOX codes without gaining a clear new tissue identity.

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.

This study shows that promoters and transcription factors coevolve antagonistically in animals and mutually in plants, leading to different transcriptional network transitions.

This paper develops a knowledge repository for Zika virus research to rapidly integrate pathophysiological knowledge during outbreaks, enabling faster response and hypothesis generation.

This study identifies three genes (ACAT1, MAP3K11, and PSMD12) that support enzalutamide resistance in castration-resistant prostate cancer cells in vitro.

This paper develops a SARS-CoV-2 proteome microarray to analyze antibody interactions at amino acid resolution and identifies epitopes and neutralizing antibodies in COVID-19 patients.

This study analyzes SARS-CoV-2 genome data to infer its evolution and population demography using phylogenetic and population genetics methods.

This study shows that prebiotic chemical composition and gut microbiota community structure influence gas production during fermentation, with common metabolisms like H2 production depending on substrate and rare ones like methane on microbial presence.

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

The paper introduces a genetically encoded 1D 1H-NMR probe for studying conformational changes in large membrane protein complexes, demonstrating its effectiveness with minimal protein and time.

This study describes a method to expand pancreatic islet clusters in vitro using hormones and chemicals, resulting in functional islet-like structures with cell type markers.

This study shows YAP1 is increased in high-grade prostate adenocarcinoma but reduced in neuroendocrine prostate cancer, with YAP1 loss activating Wnt/beta-Catenin signaling linked to NEPC development.

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.