Author

B. Groschel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:CITE-seq· 1

Frequent Co-Authors

W. R. Schief· 5 shared S. Crotty· 3 shared A. Antanasijevic· 2 shared A. B. Ward· 2 shared C. A. Cottrell· 2 shared D. G. Carnathan· 2 shared D. Sok· 2 shared E. Georgeson· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersImmunology

W. R. Schief

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Author profile →

5 papers

Recent·Most cited

Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

T. Schiffner, A. Palser, J. G. Jardine, A. Liguori, S. Menis, S. Raemisch, X. Hu, D. W. Kulp, X. Wang, J. K. Diedrich, B. Groschel, O. Kalyuzhniy, R. Tingle, K. Le, E. Georgeson, , W. R. Schief

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

bioRxiv · Jan 22, 2024 · PreprintImmunology

DeGlyPHER: an ultrasensitive method for analysis of viral spike N-glycoforms

S. Baboo, J. K. Diedrich, S. Martinez-Bartolome, X. Wang, T. Schiffner, B. Groschel, W. R. Schief, J. C. Paulson, J. R. Yates

DeGlyPHER is an ultrasensitive method to analyze viral spike N-glycoforms, assessing glycan occupancy and processing from high-mannose to complex forms at each N-glycosylation site.

bioRxiv · May 13, 2021Biochemistry

From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

A. Antanasijevic, C. A. Bowman, R. N. Kirchdoerfer, C. A. Cottrell, G. Ozorowski, A. A. Upadhyay, K. M. Cirelli, D. G. Carnathan, C. A. Enemuo, L. M. Sewall, B. Nogal, F. Zhao, B. Groschel, W. R. Schief, D. Sok, , A. B. Ward

This paper uses cryoEM and next-generation sequencing to identify monoclonal antibodies from polyclonal sera and validate their antigen-binding properties.

bioRxiv · Apr 13, 2021 · PreprintImmunology

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

A. Antanasijevic, L. M. Sewall, C. A. Cottrell, D. G. Carnathan, L. E. Jimenez, J. T. Ngo, J. B. Silverman, B. Groschel, E. Georgeson, J. Bhiman, R. Bastidas, C. LaBranche, J. D. Allen, J. Copps, H. R. Perrett, , A. B. Ward

The paper uses cryoEM to analyze polyclonal antibody responses to HIV Env immunogens in rhesus macaques, revealing structural differences in antibody binding and immunogenicity of engineered mutations and glycan sites.

bioRxiv · Jan 28, 2021Immunology

B cells expressing authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple independent mouse models

D. Huang, R. K. Abbott, C. Havenar-Daughton, P. Skog, R. Al-Kolla, B. Groschel, T. Blane, S. Menis, J. T. Tran, T. C. Thinnes, S. A. Volpi, M. Pintea, J. E. Voss, N. Phelps, R. Tingle, , S. Crotty

The paper demonstrates that authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple mouse models, validating germline-targeting vaccine design.

bioRxiv · Feb 24, 2020Immunology