Z. Shen

This study identifies the CodY regulon in two closely related S. aureus USA300 strains, revealing conserved and strain-specific regulatory patterns and metabolic roles of CodY.

This study reports two crystal structures of BCCIP, revealing structural similarities to GNATs and altered substrate-binding features, suggesting potential enzymatic activity and protein interactions.

This study identifies KIM1 as a potential receptor for SARS-CoV-2 in the kidney, showing it binds RBD with similar affinity to ACE2 and facilitates viral entry.

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

This study identifies METTL4 as the methyltransferase responsible for m6A methylation of U2 snRNA in Drosophila, confirming its enzymatic activity in vitro and in vivo.

This study identifies nitrate-induced phosphoproteomic changes in Arabidopsis roots, revealing PIN2 phosphorylation as critical for root system architecture regulation.

The paper identifies ten genes in maize that drive antibiotic biosynthesis, revealing a resilient pathway critical for disease resistance.

This study shows that deleting or inhibiting OCA-B in T cells protects mice from type-1 diabetes by reducing autoreactive CD8+ T cells and inducing anergy in CD4+ T cells.

This study identifies and characterizes the kisspeptin system in the sea cucumber Apostichopus japonicus, revealing its existence and function in a non-chordate species.

The paper shows that post-translational modification of IRR regulates alternative splicing of defense transcripts, enhancing immune signaling by deactivating a negative regulatory circuit.

This study shows IL-1RA inhibits esophageal cancer progression by suppressing VEGF through the PI3K/NF-κB pathway, suggesting it as a potential therapeutic target.