Xi‐Lei Zeng

Lipoproteins modulate the uptake and biological functionof cationic cell-penetrating peptides across the animal lineage.

This study identifies lipoprotein-mediated endocytosis as a conserved mechanism for cationic cell-penetrating peptides across animal lineages, showing it modulates their antimicrobial function.

D-alanine aminotransferase (Dat) promotes Staphylococcus aureus colonization fitness on human nasal respiratory epithelium

This study identifies D-alanine aminotransferase (Dat) as critical for Staphylococcus aureus colonization of human nasal epithelium, showing its role in D-alanine production and fitness in this environment.

Overcoming host restrictions to enable continuous passaging of human noroviruses in human intestinal enteroids

This study identifies host restriction factors limiting HuNoV passaging in HIEs and demonstrates that TAK-779 enhances viral replication and enables continuous passaging.

Insights into Human Norovirus Cultivation in Human Intestinal Enteroids

This paper reports the cultivation of human noroviruses in human intestinal enteroids, revealing segment- and strain-specific differences in viral replication and highlighting the utility of genetically modified enteroids for broader strain cultivation.

Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids

This study identifies major sources of transcriptomic variation in human intestinal organoids, showing that culture methods like substrate and format have large effects compared to experimental manipulations.