Coordinated macrophage and T cell interactions mediate response to checkpoint blockade in colorectal cancer.
Guillaume Mestrallet, Matthew Brown, Natalie Vaninov, Nam Woo Cho, Leandra G. Velazquez, Aparna Ananthanarayanan, Matthew H. Spitzer, Nicolas Vabret, Cansu Cimen Bozkus, Robert M. Samstein, Nina Bhardwaj
This study identifies T cell and macrophage subsets that mediate response to anti-PD-1 therapy in colorectal cancer, showing that combination therapy can eradicate tumors in both MMRd and MMRp settings.
Cell Reports Medicine · May 1, 2026Peer-reviewedImmunology