Author

Rishov Mukhopadhyay

Leiden University Medical CenterORCID 0000-0002-8972-8983Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Bianca D. M. van ToliD· 2 shared Gerbrand J. van der Heden van NoortiD· 2 shared Paul P. GeurinkiD· 2 shared Adán Pinto-FernándeziD· 1 shared Andrii GorelikiD· 1 shared Annemarthe G. van der VeeniD· 1 shared Ayşegül SapmaziD· 1 shared Bas C. JanseniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersMolecular Biology

Bianca D. M. van TolORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

USP24 is an ISG15 cross-reactive deubiquitinasethat mediates IFN-I production by de-ISGylatingthe RNA helicase MOV10

Rishov Mukhopadhyay, Simeon D. Draganov, Timo Oosenbrug, Jimmy J. L. L. Akkermans, Marjolein Kikkert, Klaus‐Peter Knobeloch, Günter Fritz, M Ángeles Guzmán, Sonia Zúñiga, Robbert. Q. Kim, Annemarthe G. van der Veen, Benedikt Mathias Kessler, Adán Pinto-Fernández, Paul P. Geurink, Ayşegül Sapmaz

This study identifies USP24 as a novel ISG15 cross-reactive deubiquitinase that de-ISGylates MOV10 to negatively regulate IFN-I production.

Nature Communications · Jun 19, 2026Peer-reviewedBiochemistry

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose

Max S. Kloet, Chatrin Chatrin, Rishov Mukhopadhyay, Bianca D. M. van Tol, Rebecca Smith, Sarah A. Rotman, Rayman T.N. Tjokrodirijo, Kang Zhu, Andrii Gorelik, Lucy Maginn, P.R. Elliott, Peter A. van Veelen, Dragana Ahel, Ivan Ahel, Gerbrand J. van der Heden van Noort

The paper identifies RNF114 as a specific reader of ubiquitinated ADP-ribose using a chemoproteomics approach and validates its interaction with the modified molecule.

Nature Communications · Jul 9, 2025Peer-reviewedMolecular Biology

Employing neutron-encoded monoUbs to study E2/E3 ligase activity and selectivity for assembling Ub chains

Bianca D. M. van Tol, Bjorn R. van Doodewaerd, Guinevere S. M. Lageveen‐Kammeijer, Bas C. Jansen, Joanna Liwocha, Rishov Mukhopadhyay, Manfred Wuhrer, Gerbrand J. van der Heden van Noort, Brenda Arlene Schulman, Paul P. Geurink

The paper develops a mass spectrometry-based assay to screen E2/E3 ligase pairs for their ability to form ubiquitin chains and analyze chain types.

bioRxiv · May 22, 2025 · PreprintBiochemistry