Author

Bianca D. M. van Tol

Leiden University Medical CenterORCID 0000-0001-7486-8652Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Gerbrand J. van der Heden van NoortiD· 2 shared Rishov MukhopadhyayiD· 2 shared Andrii GorelikiD· 1 shared Bas C. JanseniD· 1 shared Bjorn R. van DoodewaerdiD· 1 shared Brenda Arlene SchulmaniD· 1 shared Chatrin ChatriniD· 1 shared Dragana AheliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Gerbrand J. van der Heden van NoortORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose

Max S. Kloet, Chatrin Chatrin, Rishov Mukhopadhyay, Bianca D. M. van Tol, Rebecca Smith, Sarah A. Rotman, Rayman T.N. Tjokrodirijo, Kang Zhu, Andrii Gorelik, Lucy Maginn, P.R. Elliott, Peter A. van Veelen, Dragana Ahel, Ivan Ahel, Gerbrand J. van der Heden van Noort

The paper identifies RNF114 as a specific reader of ubiquitinated ADP-ribose using a chemoproteomics approach and validates its interaction with the modified molecule.

Nature Communications · Jul 9, 2025Peer-reviewedMolecular Biology

Employing neutron-encoded monoUbs to study E2/E3 ligase activity and selectivity for assembling Ub chains

Bianca D. M. van Tol, Bjorn R. van Doodewaerd, Guinevere S. M. Lageveen‐Kammeijer, Bas C. Jansen, Joanna Liwocha, Rishov Mukhopadhyay, Manfred Wuhrer, Gerbrand J. van der Heden van Noort, Brenda Arlene Schulman, Paul P. Geurink

The paper develops a mass spectrometry-based assay to screen E2/E3 ligase pairs for their ability to form ubiquitin chains and analyze chain types.

bioRxiv · May 22, 2025 · PreprintBiochemistry