Anneke Miedema

Identification of regional astrocyte heterogeneity associated with cuprizone-induced de- and remyelination using spatial transcriptomics

This paper uses spatial transcriptomics to identify regional astrocyte heterogeneity in cuprizone-induced demyelination and remyelination, revealing differential gene expression patterns across brain regions.

Brain macrophages acquire distinct transcriptomes prior to demyelination in multiple sclerosis

The paper identifies early transcriptomic changes in brain macrophages in MS tissue, linking them to lesion development and suggesting potential therapeutic targets.

Profiling microglia from AD donors and non-demented elderly in acute human post-mortem cortical tissue

The paper profiles microglia transcriptomes in AD donors and non-demented elderly using bulk and single-cell RNA sequencing, finding no significant differences in gene expression or subcluster composition.