Marcin W. Włodarski

Cryo-EM structures of SAMD9L reveal the arrangement and coordination of multi-domains

This study determines the cryo-EM structures of hSAMD9L and an N-terminal-truncated mutant, revealing their multi-domain architecture, dimerization, and nucleotide binding properties.

Seq2Karyotype (S2K): A Method for in-silico Karyotyping Using Single-Sample Whole-Genome Sequencing Data

Seq2Karyotype (S2K) enables in-silico karyotyping from whole-genome sequencing data, revealing intratumoral heterogeneity and evolutionary trajectories in cancer samples.

Hematological phenotypes in GATA2 deficiency syndrome arise from secondary injuries and maladaptation to proliferation

This study shows that GATA2 deficiency leads to hematological issues through bone marrow failure and maladaptation, with leukemia arising from genomic instability and proliferation defects.