Aaron W Reinke

The paper expands a microsporidia species database to include 1,795 species, revealing ecological, host, and genetic diversity, and provides a web portal for updates.

The paper shows that certain bacteria reduce microsporidia infection in C. elegans by altering host metabolism and producing inhibitory compounds.

This study identifies drug targets and resistance mechanisms in microsporidia using forward genetics in C. elegans.

The paper tests 15 yeast-targeted inhibitors against the microsporidian Nematocida parisii and finds that most are ineffective, except tunicamycin.

The Worms About Town project uses citizen science to collect nematode samples from Toronto, identifying microsporidian parasites and new nematode species.

This study screens 4,080 compounds to identify inhibitors of microsporidia spores, finding 17 effective compounds that prevent infection in C. elegans.

This study shows that microsporidia infection alters lipid metabolism in C. elegans by increasing lipase levels and decreasing triglycerides, but some host mutations do not affect infection levels.

The paper screens compounds in C. elegans to identify benzenesulfonamides that inhibit microsporidia spores, showing effectiveness against multiple species.

This study shows that parental vitamin B12 exposure in C. elegans leads to intergenerational growth acceleration and pathogen tolerance in offspring.

The paper systematically analyzes all 19 AGO proteins in C. elegans to uncover gene regulatory networks and novel phenotypes associated with their loss.

The paper investigates gene expression of Nematocida microsporidia and host responses in Caenorhabditis nematodes, finding conserved transcriptional patterns across hosts and microsporidia species.

The paper identifies a C. elegans strain with opposing resistance and susceptibility to different microsporidia species through phenotyping and genetic analysis.

The paper investigates intergenerational stress adaptations in C. elegans across four stress types, finding conserved physiological responses with trade-offs, but no long-term transgenerational gene expression changes.

The paper identifies two CSR-1 isoforms in C. elegans and shows they have distinct roles in fertility and immunity.