Author

Alexandra R. Willis

University of TorontoORCID 0000-0002-1885-9580Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron W ReinkeiD· 4 shared Adam E. Sundby· 2 shared Amanda G. Charlesworth· 2 shared Julie M. ClaycombiD· 2 shared Nicholas O. BurtoniD· 2 shared Robert X. LaoiD· 2 shared Uri Seroussi· 2 shared Winnie ZhaoiD· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersGenetics

Aaron W ReinkeORCID

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4 papers

Recent·Most cited

Parental dietary vitamin B12 causes intergenerational growth acceleration and protects offspring from pathogenic microsporidia and bacteria

Alexandra R. Willis, Winnie Zhao, Ronesh Sukhdeo, Nicholas O. Burton, Aaron W Reinke

This study shows that parental vitamin B12 exposure in C. elegans leads to intergenerational growth acceleration and pathogen tolerance in offspring.

iScience · Jun 6, 2024Peer-reviewedGenetics

A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions

Uri Seroussi, Andrew Lugowski, Lina Wadi, Robert X. Lao, Alexandra R. Willis, Winnie Zhao, Adam E. Sundby, Amanda G. Charlesworth, Aaron W Reinke, Julie M. Claycomb

The paper systematically analyzes all 19 AGO proteins in C. elegans to uncover gene regulatory networks and novel phenotypes associated with their loss.

eLife · Feb 15, 2023Peer-reviewedMolecular Biology

Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs

Nick Burton, Alexandra R. Willis, Kinsey Fisher, Fabian Braukmann, Jonathan L. Price, Lewis Stevens, L. Ryan Baugh, Aaron W Reinke, Eric Alexander Miska

The paper investigates intergenerational stress adaptations in C. elegans across four stress types, finding conserved physiological responses with trade-offs, but no long-term transgenerational gene expression changes.

eLife · Oct 6, 2021Peer-reviewedGenetics

Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility

Amanda G. Charlesworth, Uri Seroussi, Nicolas J. Lehrbach, Mathias S. Renaud, Adam E. Sundby, Ruxandra I. Molnar, Robert X. Lao, Alexandra R. Willis, Jenna R. Woock, Matthew J. Aber, Annette J. Diao, Aaron W Reinke, Gary Ruvkun, Julie M. Claycomb

The paper identifies two CSR-1 isoforms in C. elegans and shows they have distinct roles in fertility and immunity.

Nucleic Acids Research · Jul 19, 2021Peer-reviewedMolecular Biology