Author

Sarah Wyman

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Iowis ZhuiD· 2 shared Kole T. RoybaliD· 2 shared Adam M. Chazin-GrayiD· 1 shared Alejandro Chaves-Martinez· 1 shared Annie J. LiniD· 1 shared Axel Hyrenius WittsteniD· 1 shared Brian Rudolph ShyiD· 1 shared Buwei HuangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioengineering

Iowis ZhuORCID

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2 papers

Recent·Most cited

Synthetic Hybrid Receptors for Safer and Programmable T Cell Therapy

Maxwell Gabriel Foisey, Julie M. Garcia, Xun Li, Xiaoyu Yang, Claire E. Hilburger, Chloë Thienpont, Alejandro Chaves-Martinez, Serkan Belkaya, Tina Truong, Iowis Zhu, Raymond Liu, Axel Hyrenius Wittsten, Ricardo Almeida, Brian Rudolph Shy, Greg M. Allen, , Kole T. Roybal

This paper introduces Hybrid Receptors (Hybrid-Rs) to improve T cell therapy safety and programmability by combining CAR and SNIPR features for controlled gene regulation and reduced toxicity.

bioRxiv · Jan 23, 2026 · PreprintBioengineering

Engineered Receptors for Soluble Cell-to-Cell Communication

Dan Ilya Piraner, Mohamad H. Abedi, Maria J Duran Gonzalez, Adam M. Chazin-Gray, Annie J. Lin, Iowis Zhu, Pavithran T. Ravindran, Thomas Schlichthaerle, Buwei Huang, Tyler H Bearchild, David S. Lee, Sarah Wyman, Young‐wook Jun, David A. Baker, Kole T. Roybal

This paper introduces SNIPR, a synthetic receptor that responds to soluble ligands, enabling targeted CAR T-cell therapy and synthetic cell signaling.

Nature · Nov 14, 2024Peer-reviewedBioengineering