Pedro M. Alzari

Deep learning extracts MoA-specific signatures from high-throughput images of chemically and genetically perturbed Corynebacteria

This paper develops a deep learning model to identify drug modes of action from high-throughput images of chemically and genetically perturbed Corynebacteria.

Assessing Corynebacterium glutamicum as a surrogate of Mycobacterium tuberculosis for DNA gyrase inhibitor design.

This paper validates Corynebacterium glutamicum as a non-pathogenic surrogate for Mycobacterium tuberculosis to study DNA gyrase and discover new inhibitors.

Structural basis of Mycobacterium Fluoroquinolone Resistance Protein D (MfpD), a versatile pathogeny protein from the mfp conservon of Mycobacterium tuberculosis

This study defines the structural basis of MfpD function using phylogenetic, structural, and biophysical approaches, revealing its role in promoting GTP hydrolysis by MfpB through a noncanonical mechanism.

Functional dissection of Wag31 domains for septal recruitment and polar distribution during the cell cycle

This study identifies domains of Wag31 essential for septal recruitment and polar distribution during the cell cycle in Corynebacterium glutamicum.

Mechanistic insights into the allosteric regulation of cell wall hydrolase RipA in Mycobacterium tuberculosis.

This study investigates the regulatory mechanism of RipA, a cell wall hydrolase in Mtb, through structural and functional analysis of the SteAB system.

FhaA plays a key role in mycobacterial polar elongation and 1 asymmetric growth

This study identifies FhaA as essential for mycobacterial asymmetric growth and cell envelope biogenesis by analyzing its interactome and morphological effects.

Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA

The paper investigates how the MoeA enzyme evolved multifunctionality through evolutionary and structural analyses, showing its repurposing in both bacteria and eukaryotes for diverse roles.