Richard Wubbolts

This study shows E2F3 amplification in bladder cancer cells leads to premature mitosis, which can be targeted by G2/M checkpoint inhibitors.

The paper develops a live-cell imaging assay to visualize and quantify extracellular vesicle fusion with target cells, enabling study of spatiotemporal dynamics and molecular regulators of EV fusion.

EVtrace uses SILAC to trace EV-associated proteins in recipient cells, showing non-stochastic targeting of EV subpopulations to specific cell types.

This study introduces a metabolic labeling method using 5-EU and UCK2 overexpression to track RNA in donor cells, EVs, and recipient cells, enabling visualization and quantification of EV-RNA transfer.

This study demonstrates that enterovirus 2A protease is critical for viral replication and evasion of host antiviral responses through multiple mechanisms.