Author

Vikash P. Chauhan

Howard Hughes Medical InstituteORCID 0000-0001-9126-2302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Phillip A. SharpiD· 2 shared Arundeep SinghiD· 1 shared Brandon Sullivan· 1 shared Dig Bijay MahatiD· 1 shared Emily MetcalfiD· 1 shared Enrico MoisoiD· 1 shared Heena KumraiD· 1 shared Hernandez Moura SilvaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

Phillip A. SharpORCID

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2 papers

Recent·Most cited

BioengineeringNaturePeer-reviewedSep 17, 2025

Engineered prime editors with minimal genomic errors

Vikash P. Chauhan, Phillip A. Sharp, Róbert Langer

This paper designs prime editors with repositioned DNA breaks to significantly reduce indel errors while maintaining editing efficiency.

42 citationstop 1%

CRISPR screenexperimental assay

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Cancer BiologyImmunityPeer-reviewedJul 1, 2025

Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer

Dig Bijay Mahat, Heena Kumra, Sarah A Castro…·Phillip A. Sharp

This study shows mutant p53R172H in pancreatic cancer enhances immunosuppressive chemokine Cxcl1 expression via enhancer activation, reducing immune checkpoint inhibitor efficacy.

44 citationstop 1%

humanbulk RNA-seq

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