Costas Andreas Lyssiotis

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

This study shows that H2S preconditioning causes long-lasting changes in O2 metabolism, including increased P50(O2) and metabolic memory effects lasting up to 24-48 hours.

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

This study shows that G6PD deficiency accelerates pancreatic acinar-to-ductal metaplasia by enhancing NADPH production for ROS management, highlighting a metabolic role in early tumorigenesis.

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

This study shows that purine metabolism affects DNA repair and therapy resistance in glioblastoma, suggesting that targeting purine synthesis could improve treatment outcomes.

The paper integrates high-content fluorescence imaging with metabolic flux assays to improve normalization and analyze mitochondrial properties in cancer cells.

This study shows that activating PKM2 with ML-265 protects photoreceptors from stress-induced apoptosis in vitro and in vivo.

The paper analyzes targeted metabolomics data from diverse biological samples to assess measurement quality and identify metabolite dynamics across conditions.